Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.65 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.59 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.57 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.55 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.55 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.55 |
| ▸ | ACP1 | P24666 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16178553 | 0.88 | DYRK1A (0.63) | DYRK1ANPY5RDUSP3CHRM4KDM4E | |
| SCHEMBL20660046 | 0.79 | DYRK1A (0.80) | DYRK1ADUSP3CHRM4KDM4ETDP1 | |
| SCHEMBL3047328 | 0.79 | DYRK1A (0.80) | DYRK1ADUSP3CHRM4KDM4ETDP1 | |
| SCHEMBL15376502 | 0.79 | DYRK1A (1.00) | DYRK1ADUSP3CHRM4KDM4ETDP1 | |
| SCHEMBL3050805 | 0.78 | DYRK1A (0.78) | DYRK1ADUSP3CHRM4KDM4ETDP1 | |
| SCHEMBL17964767 | 0.78 | PI4KB (0.65) | DYRK1ANPY5R | |
| SCHEMBL20659925 | 0.77 | DYRK1A (0.76) | DYRK1ADUSP3CHRM4KDM4ETDP1 | |
| SCHEMBL22374141 | 0.76 | DYRK1A (0.74) | DYRK1ADUSP3CHRM4KDM4ETDP1 | |
| Hydrazine SCHEMBL20659924 | 0.76 | DYRK1A (0.74) | DYRK1ADUSP3CHRM4KDM4ETDP1 | |
| SCHEMBL9333376 | 0.76 | DYRK1A (0.74) | DYRK1ADUSP3CHRM4KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249618-A1 | Novel Piperidine Derivatives as Histamine H3 Receptor Ligands for Treatment of Depression | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | US | disclosed |
| US-20070249618-A1 | Novel Piperidine Derivatives as Histamine H3 Receptor Ligands for Treatment of Depression | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | US | disclosed |
| US-20070249618-A1 | Novel Piperidine Derivatives as Histamine H3 Receptor Ligands for Treatment of Depression | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249618-A1 | Novel Piperidine Derivatives as Histamine H3 Receptor Ligands for Treatment of Depression | HRH3, HRH1, HRH4 | DYRK1A 2603/4885NPY5R 192/4885DUSP3 4568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.