Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5464651 | 0.88 | ALDH1A1 (0.38) | TDP1GLAALDH1A1TP53GAA | |
| SCHEMBL2666690 | 0.88 | ALDH1A1 (0.38) | TDP1GLAALDH1A1TP53GAA | |
| SCHEMBL5456554 | 0.86 | KMT2A (0.37) | TDP1GLAALDH1A1TP53GAA | |
| SCHEMBL2666668 | 0.86 | HCRTR1 (0.39) | TDP1GLAALDH1A1TP53GAA | |
| SCHEMBL2666863 | 0.86 | HTT (0.41) | TDP1GLAALDH1A1TP53GAA | |
| SCHEMBL14507622 | 0.85 | KMT2A (0.40) | TDP1GLAALDH1A1TP53GAA | |
| SCHEMBL2666539 | 0.84 | MEN1 (0.43) | ALDH1A1TP53KDM4EKMT2AMEN1 | |
| SCHEMBL2662132 | 0.84 | KMT2A (0.41) | TDP1ALDH1A1TP53GAAHTT | |
| SCHEMBL2666711 | 0.83 | ALDH1A1 (0.45) | TDP1ALDH1A1GAAKDM4EKMT2A | |
| SCHEMBL2666534 | 0.82 | SMN1; SMN2 (0.47) | TDP1ALDH1A1TP53GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070117808-A1 | Substituted Cycloalkylpyrrolones As Allosteric Modulators Of Glucokinase | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117808-A1 | Substituted Cycloalkylpyrrolones As Allosteric Modulators Of Glucokinase | GCKR, GCK, GALK1 | TDP1 3460/4885GLA 850/4885ALDH1A1 2410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.