Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.48 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5464694 | 1.00 | TDP1 (0.57) | TDP1MAPTSMN1; SMN2GAANTSR1 | |
| SCHEMBL14448874 | 1.00 | TDP1 (0.57) | TDP1MAPTSMN1; SMN2GAANTSR1 | |
| SCHEMBL5481895 | 0.80 | TDP1 (0.52) | TDP1MAPTSMN1; SMN2GAANTSR1 | |
| SCHEMBL5464903 | 0.80 | NTRK1 (0.59) | TDP1MAPTSMN1; SMN2GAANTSR1 | |
| SCHEMBL725960 | 0.73 | TDP1 (1.00) | TDP1MAPTSMN1; SMN2GAANTSR1 | |
| SCHEMBL29670839 | 0.73 | TDP1 (1.00) | TDP1MAPTSMN1; SMN2GAANTSR1 | |
| 5-Methoxyisatin SCHEMBL28560213 | 0.73 | ALDH1A1 (0.84) | TDP1MAPTSMN1; SMN2GAAMDM2 | |
| SCHEMBL2825852 | 0.71 | TDP1 (0.75) | TDP1MAPTSMN1; SMN2GAANTSR1 | |
| SCHEMBL2825850 | 0.71 | TDP1 (0.75) | TDP1MAPTSMN1; SMN2GAANTSR1 | |
| SCHEMBL13207340 | 0.71 | TDP1 (0.75) | TDP1MAPTSMN1; SMN2GAANTSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070167488-A1 | Novel therapeutic use | LEO PHARMA A/S (DK) | 2007-07-19 | — | — | US | claimed |
| US-20070167488-A1 | Novel therapeutic use | LEO PHARMA A/S (DK) | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167488-A1 | Novel therapeutic use | MAG, PMP22, MYT1 | TDP1 2879/4885MAPT 1309/4885SMN1; SMN2 375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.