Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 15/20 | 0.72 |
| ▸ | HTR1A | P08908 | 14/20 | 0.72 |
| ▸ | HTR1D | P28221 | 12/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | HTR2A | P28223 | 1/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5469807 | 0.97 | HTR1B (0.67) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL7600228 | 0.94 | HTR1B (0.67) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL5471454 | 0.92 | HTR1B (0.71) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL14960974 | 0.86 | HTR1B (0.83) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL14960972 | 0.86 | HTR1B (0.83) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL14960982 | 0.86 | HTR1B (0.83) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL14960987 | 0.86 | HTR1B (0.83) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL14960969 | 0.86 | HTR1B (0.83) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL14960986 | 0.86 | HTR1B (0.83) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL14960983 | 0.86 | HTR1B (0.83) | HTR1BHTR1AHTR1DMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606887-A1 | DIINDOLYLMETHANE, PRECURSOR AND DERIVATIVES THEREOF IN PREPARATION OF MEDICAMENTS FOR TREATING LIVER DISEASES | Nanjing University (CN) | 2013-06-26 | — | — | EP | claimed |
| US-20040058897-A1 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2004-03-25 | — | — | US | claimed |
| US-6605605-B2 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2003-08-12 | — | — | US | claimed |
| EP-0971890-B1 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | TEXAS A & M UNIV SYS (US) | 2002-11-27 | — | — | EP | claimed |
| US-20020058648-A1 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2002-05-16 | — | — | US | claimed |
| EP-0971890-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2000-01-19 | — | — | EP | claimed |
| US-5948808-A | Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 1999-09-07 | — | — | US | claimed |
| WO-1998050357-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 1998-11-12 | — | — | WO | claimed |
| EP-2606887-A1 | DIINDOLYLMETHANE, PRECURSOR AND DERIVATIVES THEREOF IN PREPARATION OF MEDICAMENTS FOR TREATING LIVER DISEASES | Nanjing University (CN) | 2013-06-26 | — | — | EP | disclosed |
| US-20070004691-A1 | Antitumoral combinations containing et-743 and a cruciferous and a cruciferous indole compound | PHARMA MAR, S.A.U. (ES) | 2007-01-04 | — | — | US | disclosed |
| EP-1675592-A1 | IMPROVED ANTITUMORAL COMBINATIONS CONTAINING ET-743 AND A CRUCIFEROUS INDOLE COMPOUND | Pharma Mar, S.A.U. (ES) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005039584-A1 | IMPROVED ANTITUMORAL COMBINATIONS CONTAINING ET-743 AND A CRUCIFEROUS AND A CRUCIFEROUS INDOLE COMPOUND | PHARMA MAR, S.A.U. (ES) | 2005-05-06 | — | — | WO | disclosed |
| US-20040058897-A1 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2004-03-25 | — | — | US | disclosed |
| US-6605605-B2 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2003-08-12 | — | — | US | disclosed |
| EP-0971890-B1 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | TEXAS A & M UNIV SYS (US) | 2002-11-27 | — | — | EP | disclosed |
| US-20020058648-A1 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2002-05-16 | — | — | US | disclosed |
| EP-0971890-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2000-01-19 | — | — | EP | disclosed |
| US-5948808-A | Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 1999-09-07 | — | — | US | disclosed |
| WO-1998050357-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 1998-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004691-A1 | Antitumoral combinations containing et-743 and a cruciferous and a cruciferous indole compound | ELF3, TEAD4, CUL3 | HTR1B 1733/4885HTR1A 1391/4885HTR1D 1556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.