Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5460845 | 0.86 | TDP1 (0.57) | MAPK1SMN1; SMN2ALDH1A1MAPTTDP1 | |
| SCHEMBL24861312 | 0.86 | SMN1; SMN2 (0.49) | MAPK1SMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL3727437 | 0.83 | TDP1 (0.51) | MAPK1SMN1; SMN2ALDH1A1TDP1KMT2A | |
| SCHEMBL3796044 | 0.83 | MAPK1 (0.61) | MAPK1SMN1; SMN2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL31031180 | 0.83 | MAPK1 (0.61) | MAPK1SMN1; SMN2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL12053309 | 0.82 | GPR35 (0.50) | MAPK1SMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL11871085 | 0.82 | SMN1; SMN2 (0.49) | MAPK1SMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL283180 | 0.81 | SMN1; SMN2 (0.47) | MAPK1SMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL11398188 | 0.80 | TDP1 (0.56) | MAPK1SMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL5473367 | 0.80 | CHEK1 (0.46) | SMN1; SMN2ALDH1A1L3MBTL1KDM4ETBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010537-A1 | Fused pyramidine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-11 | — | — | US | disclosed |
| US-20070010537-A1 | Fused pyramidine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-11 | — | — | US | disclosed |
| EP-1657238-A1 | FUSED PYRIMIDINE DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2006-05-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010537-A1 | Fused pyramidine derivative and use thereof | NR5A1, GNRHR, RXFP3 | MAPK1 1022/4885SMN1; SMN2 2437/4885ALDH1A1 1875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.