SCHEMBL5467974

SCHEMBL5467974

Cc1nn(-c2cc(NS(C)(=O)=O)c(Cl)cc2Cl)c(=O)n1C(Cl)Cl

nearest known ligand 0.81

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PPOX P50336 1/20 0.81
MAOB P27338 1/20 0.32
HPGD P15428 2/20 0.32
GAA P10253 1/20 0.32
MAPK1 P28482 1/20 0.32
ADRB3 P13945 2/20 0.31
KDM4E B2RXH2 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
DHODH Q02127 1/20 0.31
PTGS1 P23219 1/20 0.31
PTGS2 P35354 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30958745 0.91 PPOX (0.85) PPOXMAOBHPGDGAAMAPK1
Sulfentrazone SCHEMBL18489655 0.89 PPOX (1.00) PPOX
Sulfentrazone SCHEMBL44683 0.89 PPOX (1.00) PPOX
Sulfentrazone SCHEMBL29195861 0.88 PPOX (0.98) PPOX
Sulfentrazone SCHEMBL28519794 0.88 PPOX (0.98) PPOX
Sulfentrazone SCHEMBL27961987 0.88 PPOX (0.98) PPOX
Sulfentrazone SCHEMBL20723669 0.88 PPOX (0.98) PPOX
SCHEMBL13006819 0.82 PPOX (0.87) PPOX
SCHEMBL20303399 0.81 PPOX (0.72) PPOXHPGDGAAMAPK1PTGS2
Sulfentrazone SCHEMBL22163823 0.80 PPOX (0.80) PPOX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070010402-A1 Novel herbicides, usage thereof, novel thienopyrimidine derivatives, intermediates of the same, and process for production thereof NIHON NOHYAKU CO., LTD., (JP) 2007-01-11 US disclosed
EP-1544202-A1 NOVEL HERBICIDES, USAGE THEREOF, NOVEL THIENOPYRIMIDINE DERIVATIVES, INTERMEDIATES OF THE SAME, AND PROCESS FOR PRODUCTION THEREOF Nihon Nohyaku Co., Ltd. (JP) 2005-06-22 EP disclosed
US-6365753-B1 EXCELLENT PREFERENTIAL EFFECTS ON WEEDS; GRASSES; NONPHYTOTOXIC TO CROPS E.G. WHEAT; BARLEY; CORN MITSUBISHI CHEMICAL CORPORATION (JP) 2002-04-02 US disclosed
EP-1097923-A1 PHTHALIMIDES AND HERBICIDE CONTAINING THE SAME AS ACTIVE COMPONENT MITSUBISHI CHEMICAL CORPORATION (JP) 2001-05-09 EP disclosed
EP-0786453-B1 Novel phthalimide compounds and herbicides containing the same MITSUBISHI CHEM CORP (JP) 2000-08-16 EP disclosed
EP-0786453-A1 Novel phthalimide compounds and herbicides containing the same Mitsubishi Chemical Corporation (JP) 1997-07-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070010402-A1 Novel herbicides, usage thereof, novel thienopyrimidine derivatives, intermediates of the same, and process for production thereof DDT, DPYD, DHODH PPOX 96/4885MAOB 926/4885HPGD 450/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.