SCHEMBL5468656

SCHEMBL5468656

CCc1nn(C(C)C)c2nc(-c3ccn(-c4ncc(N5CCOCC5)cn4)n3)ccc12

nearest known ligand 0.33

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CARM1 Q86X55 1/20 0.33
FLT3 P36888 2/20 0.33
SRC P12931 1/20 0.33
TNIK Q9UKE5 1/20 0.31
KHK P50053 1/20 0.31
PCSK9 Q8NBP7 1/20 0.31
STAT6 P42226 1/20 0.30
PIK3CA P42336 1/20 0.30
MTOR P42345 1/20 0.30
SUV39H2 Q9H5I1 2/20 0.30
CSF1R P07333 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5368408 0.83
SCHEMBL14362844 0.77 KHK (0.37) CARM1KHK
SCHEMBL5356591 0.76 ALDH1A1 (0.38) SRCKHK
SCHEMBL5347383 0.73 ACVR1 (0.33) SRCPIK3CAMTOR
SCHEMBL5322571 0.71 JMJD6 (0.32)
SCHEMBL5463772 0.67
SCHEMBL5457981 0.66 PIK3CA (0.32) SRCPIK3CAMTOR
SCHEMBL5365430 0.64 ALDH1A1 (0.39) KHK
SCHEMBL5367244 0.64 CDK2 (0.39) KHK
SCHEMBL5351228 0.64 PDE1A (0.36) PIK3CAMTOR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070254913-A1 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICALS CORPORATION 2007-11-01 US claimed
WO-2007123953-A2 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2007-11-01 WO disclosed
US-20070254913-A1 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICALS CORPORATION 2007-11-01 US disclosed
US-20070254913-A1 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICALS CORPORATION 2007-11-01 US disclosed
US-20070254913-A1 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICALS CORPORATION 2007-11-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070254913-A1 Phosphodiesterase 4 inhibitors PDE4A, PDE4B, PDE12 CARM1 781/4885FLT3 3183/4885SRC 4406/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.