Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.60 |
| ▸ | HPGD | P15428 | 6/20 | 0.60 |
| ▸ | RAB9A | P51151 | 6/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MITF | O75030 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | XBP1 | P17861 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26162620 | 0.84 | MRGPRX4 (0.68) | NPC1HPGDRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL8283224 | 0.83 | FFAR4 (0.56) | MRGPRX4MAPTHTR1AADRA1DADRA1A | |
| SCHEMBL12173115 | 0.81 | MRGPRX4 (0.58) | NPC1RAB9ASMN1; SMN2TP53XBP1 | |
| SCHEMBL6553017 | 0.81 | HPGD (0.66) | NPC1HPGDRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL31556117 | 0.81 | HPGD (0.61) | NPC1HPGDRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL29434222 | 0.80 | MEN1 (0.60) | NPC1HPGDRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL5263840 | 0.80 | MEN1 (0.60) | NPC1HPGDRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL3047774 | 0.80 | HPGD (0.69) | NPC1HPGDRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL6957559 | 0.79 | MRGPRX4 (0.54) | NPC1RAB9ASMN1; SMN2TP53XBP1 | |
| SCHEMBL12851580 | 0.79 | RXRA (0.57) | MRGPRX4CYP2C19RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070287738-A1 | Substituted Cyanopyridines as protein kinase inhibitors | WYETH | 2007-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287738-A1 | Substituted Cyanopyridines as protein kinase inhibitors | CNKSR1, MAP3K1, MAP3K6 | NPC1 2023/4885HPGD 2446/4885RAB9A 2805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.