Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25A | P30304 | 1/20 | 0.55 |
| ▸ | CNR2 | P34972 | 11/20 | 0.54 |
| ▸ | ICMT | O60725 | 1/20 | 0.54 |
| ▸ | CNR1 | P21554 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5472032 | 0.90 | CDC25A (0.63) | CDC25ACNR2ICMTCNR1KDM4E | |
| SCHEMBL5462804 | 0.88 | CDC25A (0.70) | CDC25ACNR2ICMTCNR1 | |
| SCHEMBL11375790 | 0.88 | IL6ST (0.53) | CDC25ACNR2ICMTCNR1KDM4E | |
| SCHEMBL10650270 | 0.87 | CNR2 (0.58) | CDC25ACNR2ICMTCNR1KDM4E | |
| SCHEMBL11063691 | 0.87 | CNR2 (0.52) | CDC25ACNR2ICMTCNR1KDM4E | |
| SCHEMBL12558504 | 0.86 | CNR2 (0.58) | CDC25ACNR2ICMTCNR1KDM4E | |
| SCHEMBL5469549 | 0.85 | CYP19A1 (0.59) | CDC25AICMTALDH1A1 | |
| SCHEMBL15747715 | 0.82 | CDC25A (0.80) | CDC25ACNR2ICMTCNR1KDM4E | |
| SCHEMBL7749067 | 0.81 | HTR2A (0.66) | CDC25ACNR2ICMTCNR1HTR6 | |
| SCHEMBL13061260 | 0.80 | CDC25A (0.60) | CDC25ACNR2ICMTCNR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606887-A1 | DIINDOLYLMETHANE, PRECURSOR AND DERIVATIVES THEREOF IN PREPARATION OF MEDICAMENTS FOR TREATING LIVER DISEASES | Nanjing University (CN) | 2013-06-26 | — | — | EP | claimed |
| US-20040058897-A1 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2004-03-25 | — | — | US | claimed |
| US-6605605-B2 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2003-08-12 | — | — | US | claimed |
| EP-0971890-B1 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | TEXAS A & M UNIV SYS (US) | 2002-11-27 | — | — | EP | claimed |
| US-20020058648-A1 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2002-05-16 | — | — | US | claimed |
| EP-0971890-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2000-01-19 | — | — | EP | claimed |
| US-5948808-A | Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 1999-09-07 | — | — | US | claimed |
| WO-1998050357-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 1998-11-12 | — | — | WO | claimed |
| EP-2606887-A1 | DIINDOLYLMETHANE, PRECURSOR AND DERIVATIVES THEREOF IN PREPARATION OF MEDICAMENTS FOR TREATING LIVER DISEASES | Nanjing University (CN) | 2013-06-26 | — | — | EP | disclosed |
| US-20070004691-A1 | Antitumoral combinations containing et-743 and a cruciferous and a cruciferous indole compound | PHARMA MAR, S.A.U. (ES) | 2007-01-04 | — | — | US | disclosed |
| EP-1675592-A1 | IMPROVED ANTITUMORAL COMBINATIONS CONTAINING ET-743 AND A CRUCIFEROUS INDOLE COMPOUND | Pharma Mar, S.A.U. (ES) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005039584-A1 | IMPROVED ANTITUMORAL COMBINATIONS CONTAINING ET-743 AND A CRUCIFEROUS AND A CRUCIFEROUS INDOLE COMPOUND | PHARMA MAR, S.A.U. (ES) | 2005-05-06 | — | — | WO | disclosed |
| US-20040058897-A1 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2004-03-25 | — | — | US | disclosed |
| US-6605605-B2 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2003-08-12 | — | — | US | disclosed |
| EP-0971890-B1 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | TEXAS A & M UNIV SYS (US) | 2002-11-27 | — | — | EP | disclosed |
| US-20020058648-A1 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2002-05-16 | — | — | US | disclosed |
| EP-0971890-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2000-01-19 | — | — | EP | disclosed |
| US-5948808-A | Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 1999-09-07 | — | — | US | disclosed |
| WO-1998050357-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 1998-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004691-A1 | Antitumoral combinations containing et-743 and a cruciferous and a cruciferous indole compound | ELF3, TEAD4, CUL3 | CDC25A 917/4885CNR2 939/4885ICMT 2982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.