Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.62 |
| ▸ | HSP90AB1 | P08238 | 8/20 | 0.62 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1779006 | 0.87 | HSP90AA1 (0.66) | HSP90AA1HSP90AB1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL5457745 | 0.87 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1HPGDTRAP1 | |
| SCHEMBL5471332 | 0.84 | HSP90AA1 (0.62) | HSP90AA1HSP90AB1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL5463191 | 0.84 | HSP90AA1 (0.62) | HSP90AA1HSP90AB1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL4620866 | 0.84 | HSP90AA1 (0.65) | HSP90AA1HSP90AB1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL5470114 | 0.84 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1GPBAR1HPGDALDH1A1 | |
| SCHEMBL14582379 | 0.83 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL5465114 | 0.83 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL5459772 | 0.83 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL4618394 | 0.83 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1HPGDALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070027150-A1 | 2-Amino-quinazolin-5-ones | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2007-02-01 | — | — | US | disclosed |
| US-20070027150-A1 | 2-Amino-quinazolin-5-ones | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2007-02-01 | — | — | US | disclosed |
| US-20070027150-A1 | 2-Amino-quinazolin-5-ones | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027150-A1 | 2-Amino-quinazolin-5-ones | TK1, TK2, SLC1A5 | HSP90AA1 3373/4885HSP90AB1 3036/4885GPBAR1 1715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.