Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 14/20 | 0.41 |
| ▸ | CTSL | P07711 | 10/20 | 0.41 |
| ▸ | CTSK | P43235 | 6/20 | 0.41 |
| ▸ | CTSB | P07858 | 7/20 | 0.36 |
| ▸ | TACR2 | P21452 | 2/20 | 0.33 |
| ▸ | CTSH | P09668 | 1/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14491116 | 0.92 | CTSS (0.44) | CTSSCTSLCTSKCTSB | |
| SCHEMBL6842993 | 0.92 | CTSS (0.44) | CTSSCTSLCTSKCTSB | |
| SCHEMBL6847855 | 0.89 | CTSS (0.43) | CTSSCTSLCTSKCTSBTACR2 | |
| SCHEMBL6847007 | 0.86 | CTSS (0.43) | CTSSCTSLCTSKCTSBTACR2 | |
| SCHEMBL5445303 | 0.85 | KMT2A (0.35) | POLB | |
| SCHEMBL5436195 | 0.84 | CTSS (0.46) | CTSSCTSLCTSKCTSBCTSH | |
| SCHEMBL6743322 | 0.84 | CTSS (0.46) | CTSSCTSLCTSKCTSBCTSH | |
| SCHEMBL5445598 | 0.83 | KMT2A (0.33) | POLB | |
| SCHEMBL5438734 | 0.80 | KMT2A (0.34) | — | |
| SCHEMBL1557679 | 0.75 | CTSS (0.50) | CTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196099-B2 | Compounds and compositions as cathepsin inhibitors | AVENTIS PHARMACEUTICALS INC. (US) | 2007-03-27 | — | — | US | disclosed |