Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.66 |
| ▸ | RAB9A | P51151 | 7/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5472161 | 1.00 | NPC1 (0.66) | NPC1RAB9AKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL647310 | 0.83 | NPC1 (0.57) | NPC1RAB9AKMT2AHPGDPDE10A | |
| SCHEMBL647311 | 0.83 | NPC1 (0.57) | NPC1RAB9AKMT2AHPGDPDE10A | |
| SCHEMBL28409561 | 0.80 | NPC1 (1.00) | NPC1RAB9AKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL28056008 | 0.74 | NPC1 (0.72) | NPC1RAB9AKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL16684735 | 0.74 | NPC1 (0.69) | NPC1RAB9AKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL3775105 | 0.72 | NPC1 (0.62) | NPC1RAB9AKMT2AHPGD | |
| SCHEMBL23573374 | 0.72 | GAA (0.68) | NPC1RAB9AKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL3197126 | 0.72 | GAA (0.68) | NPC1RAB9AKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL3197121 | 0.72 | GAA (0.68) | NPC1RAB9AKMT2AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070238753-A1 | Pharmaceutical Compositions as Inhibitors of Dipeptidyl Peptidase-IV (DPP-IV) | MADAR DAVID J | 2007-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070238753-A1 | Pharmaceutical Compositions as Inhibitors of Dipeptidyl Peptidase-IV (DPP-IV) | DPP4, DPP3, DPP7 | NPC1 637/4885RAB9A 4226/4885KMT2A 3383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.