SCHEMBL547356

SCHEMBL547356

O=CC[S]

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL702916 0.67
SCHEMBL65061 0.59
Malonaldehyde SCHEMBL10949336 0.59 ALDH1A1 (0.42)
SCHEMBL8844029 0.59
SCHEMBL2480102 0.59 HIF1A (0.64)
SCHEMBL5918577 0.59
Malonaldehyde SCHEMBL16287 0.59
SCHEMBL35238 0.59
Malonaldehyde SCHEMBL8182493 0.56
SCHEMBL9301776 0.56

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 340 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12037585-B2 Oligonucleotides for tissue specific gene expression modulation UNIVERSITY OF MASSACHUSETTS (US) 2024-07-16 US disclosed
US-12024706-B2 Modified oligonucleotides targeting SNPs UNIVERSITY OF MASSACHUSETTS (US) 2024-07-02 US disclosed
WO-2024129710-A1 CARBOHYDRATE CONJUGATES FOR THE DELIVERY OF THERAPEUTIC OLIGONUCLEOTIDES UNIVERSITY OF MASSACHUSETTS (US) 2024-06-20 WO disclosed
US-20240191230-A1 CONJUGATES OF SIRNA AND ANTISENSE OLIGONUCLEOTIDES (SIRNASO) AND METHODS OF USE IN GENE SILENCING UNIVERSITY OF MASSACHUSETTS 2024-06-13 US disclosed
US-20240182904-A1 OLIGONUCLEOTIDES TARGETING S6K1 UNIVERSITY OF MASSACHUSETTS 2024-06-06 US disclosed
US-20240173420-A1 OCULAR DELIVERY OF OLIGONUCLEOTIDES UNIVERSITY OF MASSACHUSETTS 2024-05-30 US disclosed
US-20240141362-A1 MODIFIED OLIGONUCLEOTIDES WITH INCREASED STABILITY UNIV MASSACHUSETTS (US) 2024-05-02 US disclosed
EP-4359539-A1 OPTIMIZED ANTI-FLT1 OLIGONUCLEOTIDE COMPOUNDS FOR TREATMENT OF PREECLAMPSIA AND OTHER ANGIOGENIC DISORDERS University Of Massachusetts (US) 2024-05-01 EP disclosed
EP-4359537-A1 OLIGONUCLEOTIDES FOR IFN-GAMMA SIGNALING PATHWAY MODULATION University Of Massachusetts (US) 2024-05-01 EP disclosed
US-20240132892-A1 OLIGONUCLEOTIDE-BASED MODULATION OF C9orf72 UNIV MASSACHUSETTS (US) 2024-04-25 US disclosed
WO-2004029212-A2 IN VIVO GENE SILENCING BY CHEMICALLY MODIFIED AND STABLE SIRNA UNIVERSITY OF MASSACHUSETTS (US) 2004-04-08 WO disclosed
WO-2004014933-A1 COMPOSITIONS FOR RNA INTERFERENCE AND METHODS OF USE THEREOF UNIVERSITY OF MASSACHUSETTS (US) 2004-02-19 WO disclosed
EP-0199604-B1 PROCESSING METHOD FOR LIGHT-SENSITIVE SILVER HALIDE COLOR PHOTOGRAPHIC MATERIAL KONICA CORPORATION (JP) 1990-12-27 EP disclosed
EP-0095340-B1 PROCESSES FOR MAKING 3-METHYLTHIOPHENE-2-CARBOXALDEHYDE AND INTERMEDIATES THEREFOR PFIZER INC. (US) 1986-08-13 EP disclosed
EP-0162217-A1 1,2,4-Triazacycloalcadiene derivatives CIBA-GEIGY AG (CH) 1985-11-27 EP disclosed
US-4476312-A Processes for making 3-methylthiophene-2-carboxaldehyde and intermediates therefor PFIZER INC. (US) 1984-10-09 US disclosed
US-4471139-A Processes for making 3-methylthiophene-2-carboxaldehyde and intermediates therefor PFIZER INC. (US) 1984-09-11 US disclosed
EP-0107928-A1 Vinylthioacetamido oxacephalosporin derivatives, and intermediates therefor, their preparation, formulations containing the same and their antibacterial use SHIONOGI & CO., LTD. (JP) 1984-05-09 EP disclosed
EP-0095340-A1 Processes for making 3-methylthiophene-2-carboxaldehyde and intermediates therefor PFIZER INC. (US) 1983-11-30 EP disclosed
US-3945989-A Fluoro triazine containing water insoluble azo dyestuff CIBA-GEIGY AG (CH) 1976-03-23 US disclosed