Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 16/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.57 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20095356 | 1.00 | NAMPT (0.69) | NAMPTCYP3A4CYP2C9HDAC3HDAC1 | |
| SCHEMBL5474275 | 1.00 | NAMPT (0.69) | NAMPTCYP3A4CYP2C9HDAC3HDAC1 | |
| SCHEMBL31006646 | 1.00 | NAMPT (0.69) | NAMPTCYP3A4CYP2C9HDAC3HDAC1 | |
| SCHEMBL31597003 | 0.99 | NAMPT (0.68) | NAMPTCYP3A4CYP2C9HDAC3HDAC1 | |
| Hydrochloric Acid SCHEMBL5463945 | 0.99 | NAMPT (0.68) | NAMPTCYP3A4CYP2C9HDAC3HDAC1 | |
| Hydrochloric Acid SCHEMBL5463942 | 0.99 | NAMPT (0.68) | NAMPTCYP3A4CYP2C9HDAC3HDAC1 | |
| Hydrochloric Acid SCHEMBL19834816 | 0.99 | NAMPT (0.68) | NAMPTCYP3A4CYP2C9HDAC3HDAC1 | |
| Trifluoroacetic Acid SCHEMBL30828922 | 0.94 | NAMPT (0.66) | NAMPTCYP3A4CYP2C9HDAC3HDAC1 | |
| SCHEMBL28376292 | 0.85 | NAMPT (0.82) | NAMPTCYP3A4CYP2C9HDAC3HDAC1 | |
| Hydrochloric Acid SCHEMBL19834839 | 0.85 | NAMPT (0.52) | NAMPTCYP3A4CYP2C9HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241745-B2 | Pyridyl alkene and pyridyl alkine acid amides as cytostatics and immunosupressives | ASTELLAS PHARMA GMBH (DE) | 2007-07-10 | — | — | US | disclosed |
| US-20070142377-A1 | Pyridyl Alkene and Pyridyl Alkine-Acid Amides as Cytostatics and Immunosuppressives | BIEDERMANN ELFI | 2007-06-21 | — | — | US | disclosed |
| CN-1546472-A | Pyridyl alkane acid amides as cytostatics and immunosupressives | ���ָ���ҩ�ɷ�����˾ | 2004-11-17 | — | — | CN | disclosed |
| CN-1152032-C | Pyridylalkane-and pyridylalkyne-acid amides as cytostatics and immunosuppressants | ���ָ���ҩ�ɷ�����˾ | 2004-06-02 | — | — | CN | disclosed |
| US-20040009967-A1 | Pyridyl alkene- and pyridyl alkine- acid amides as cytostatics and immuno-suppressives | KLINGE PHARMA GMBH | 2004-01-15 | — | — | US | disclosed |
| EP-0923570-B1 | PYRIDYL ALKENE- AND PYRIDYL ALKINE- ACID AMIDES AS CYTOSTATICS AND IMMUNOSUPPRESSIVES | FUJISAWA DEUTSCHLAND GMBH (DE) | 2002-09-25 | — | — | EP | disclosed |
| CN-1228777-A | Pyridylalkane-and pyridylalkyne-acid amides as cytostatics and immunosuppressants | KLINGE CO CHEM PHARM FAB (DE) | 1999-09-15 | — | — | CN | disclosed |
| EP-0923570-A1 | PYRIDYL ALKENE- AND PYRIDYL ALKINE- ACID AMIDES AS CYTOSTATICS AND IMMUNOSUPPRESSIVES | Klinge Pharma GmbH (DE) | 1999-06-23 | — | — | EP | disclosed |
| WO-1997048696-A1 | PYRIDYL ALKENE- AND PYRIDYL ALKINE- ACID AMIDES AS CYTOSTATICS AND IMMUNOSUPPRESSIVES | KLINGE PHARMA GMBH (DE) | 1997-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040009967-A1 | Pyridyl alkene- and pyridyl alkine- acid amides as cytostatics and immuno-suppressives | IDO1, ALK, ARG1 | NAMPT 350/4885CYP3A4 1520/4885CYP2C9 2017/4885 |
| US-20070142377-A1 | Pyridyl Alkene and Pyridyl Alkine-Acid Amides as Cytostatics and Immunosuppressives | ALK, TYMP, PDCD1 | NAMPT 151/4885CYP3A4 1137/4885CYP2C9 1645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.