Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5474286 | 0.81 | ALDH1A1 (0.43) | ALDH1A1MAPTTSHRMEN1KMT2A | |
| SCHEMBL5864166 | 0.80 | ALDH1A1 (0.50) | ALDH1A1MAPTTSHRPOLBMEN1 | |
| SCHEMBL5466819 | 0.80 | ALDH1A1 (0.49) | ALDH1A1TSHRPOLBMEN1KMT2A | |
| SCHEMBL8893316 | 0.80 | TSHR (0.59) | ALDH1A1MAPTTSHRPOLBMEN1 | |
| SCHEMBL8547913 | 0.79 | ALDH1A1 (0.54) | ALDH1A1MAPTTSHRPOLBMEN1 | |
| SCHEMBL28067351 | 0.78 | ALDH1A1 (0.61) | ALDH1A1MAPTTSHRPOLBL3MBTL1 | |
| SCHEMBL5863528 | 0.77 | TSHR (0.64) | ALDH1A1MAPTTSHRPOLBMEN1 | |
| SCHEMBL4415542 | 0.77 | TSHR (0.64) | ALDH1A1MAPTTSHRPOLBMEN1 | |
| SCHEMBL3803733 | 0.77 | TSHR (0.58) | ALDH1A1MAPTTSHRPOLBMEN1 | |
| SCHEMBL10649262 | 0.76 | CYP3A4 (0.51) | ALDH1A1MAPTTSHRPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010537-A1 | Fused pyramidine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-11 | — | — | US | disclosed |
| EP-1657238-A1 | FUSED PYRIMIDINE DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2006-05-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010537-A1 | Fused pyramidine derivative and use thereof | NR5A1, GNRHR, RXFP3 | ALDH1A1 1875/4885MAPT 4777/4885TSHR 101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.