Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.60 |
| ▸ | RAF1 | P04049 | 8/20 | 0.60 |
| ▸ | KDR | P35968 | 11/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | BCR | P11274 | 1/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL545580 | 0.87 | BRAF (0.63) | BRAFRAF1KDRABL1BCR | |
| SCHEMBL546225 | 0.86 | BRAF (0.62) | BRAFRAF1KDRABL1BCR | |
| SCHEMBL545001 | 0.86 | BRAF (0.75) | BRAFRAF1KDR | |
| SCHEMBL544983 | 0.85 | BRAF (0.61) | BRAFRAF1KDRABL1BCR | |
| SCHEMBL545906 | 0.82 | BRAF (0.68) | BRAFRAF1KDR | |
| SCHEMBL545722 | 0.82 | BRAF (0.76) | BRAFRAF1KDR | |
| SCHEMBL5428348 | 0.81 | BRAF (0.77) | BRAFRAF1KDR | |
| SCHEMBL545994 | 0.81 | BRAF (0.68) | BRAFRAF1KDR | |
| SCHEMBL545615 | 0.81 | BRAF (0.81) | BRAFRAF1KDRABL1BCR | |
| SCHEMBL545829 | 0.80 | RAF1 (0.58) | BRAFRAF1KDRABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | claimed |