Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | EBP | Q15125 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5474373 | 0.82 | KCNH2 (0.52) | KCNH2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL5468540 | 0.82 | KCNH2 (0.53) | KCNH2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL5460550 | 0.81 | KCNH2 (0.51) | KCNH2OPRL1OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL5457614 | 0.81 | KCNH2 (0.52) | KCNH2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL5460383 | 0.81 | KCNH2 (0.54) | KCNH2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL5468561 | 0.78 | KCNH2 (0.64) | KCNH2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL5464120 | 0.78 | KCNH2 (0.61) | KCNH2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL5457442 | 0.78 | KCNH2 (0.63) | KCNH2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL5457660 | 0.76 | KCNH2 (0.59) | KCNH2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL5751838 | 0.74 | KCNH2 (0.69) | KCNH2OPRL1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070021414-A1 | 1-'2-(4-Hydroxyphenyl)-2-hydroxyethyl!-piperidin-4-ol compounds as nmda receptor antagonists | PFIZER, INC. | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021414-A1 | 1-'2-(4-Hydroxyphenyl)-2-hydroxyethyl!-piperidin-4-ol compounds as nmda receptor antagonists | GRIN1, GRIN3A, GRIN2C | KCNH2 163/4885OPRL1 6/4885OPRM1 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.