Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.74 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | MGLL | Q99685 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5475256 | 1.00 | HSD11B1 (0.74) | HSD11B1POLBALDH1A1KMT2AMEN1 | |
| SCHEMBL5472861 | 0.93 | HSD11B1 (0.86) | HSD11B1KMT2ARAB9AMGLLLMNA | |
| SCHEMBL5472856 | 0.93 | HSD11B1 (0.86) | HSD11B1KMT2ARAB9AMGLLLMNA | |
| SCHEMBL21926547 | 0.91 | POLB (0.64) | HSD11B1POLBALDH1A1KMT2AMEN1 | |
| SCHEMBL21926384 | 0.90 | POLB (0.69) | HSD11B1POLBALDH1A1KMT2AMEN1 | |
| SCHEMBL5486724 | 0.85 | HSD11B1 (0.76) | HSD11B1POLBALDH1A1KMT2AMEN1 | |
| SCHEMBL5486720 | 0.85 | HSD11B1 (0.76) | HSD11B1POLBALDH1A1KMT2AMEN1 | |
| SCHEMBL21928849 | 0.85 | HSD11B1 (0.71) | HSD11B1ALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL5474311 | 0.85 | HSD11B1 (0.68) | HSD11B1POLBALDH1A1KMT2AMEN1 | |
| SCHEMBL5474315 | 0.85 | HSD11B1 (0.68) | HSD11B1POLBALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070112000-A1 | Chemical compounds | ASTRAZENECA R&D ALDERLEY (GB) | 2007-05-17 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112000-A1 | Chemical compounds | HSD11B1, CYP11B1, HSD11B2 | HSD11B1 1/4885POLB 2868/4885ALDH1A1 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.