Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 7/20 | 1.00 |
| ▸ | JAK2 | O60674 | 2/20 | 1.00 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.86 |
| ▸ | RET | P07949 | 6/20 | 0.62 |
| ▸ | FLT3 | P36888 | 3/20 | 0.62 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.62 |
| ▸ | RAF1 | P04049 | 2/20 | 0.62 |
| ▸ | ABL1 | P00519 | 2/20 | 0.62 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.62 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.60 |
| ▸ | FLT1 | P17948 | 2/20 | 0.60 |
| ▸ | KDR | P35968 | 2/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.57 |
| ▸ | PAK4 | O96013 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5476260 | 1.00 | JAK3 (1.00) | JAK3JAK2LRRK2RETFLT3 | |
| SCHEMBL21585712 | 0.93 | LRRK2 (1.00) | JAK3JAK2LRRK2RETFLT3 | |
| SCHEMBL6962375 | 0.81 | JAK3 (0.69) | JAK3JAK2LRRK2RETFLT3 | |
| SCHEMBL6962386 | 0.81 | JAK3 (0.69) | JAK3JAK2LRRK2RETFLT3 | |
| SCHEMBL19442413 | 0.81 | JAK3 (0.69) | JAK3JAK2LRRK2RETFLT3 | |
| SCHEMBL5988205 | 0.80 | PDPK1 (0.68) | JAK3JAK2LRRK2RETFLT3 | |
| SCHEMBL19442446 | 0.80 | JAK3 (0.66) | JAK3JAK2LRRK2RETFLT3 | |
| SCHEMBL5989169 | 0.78 | JAK3 (0.68) | JAK3JAK2LRRK2RETFLT3 | |
| SCHEMBL6174867 | 0.78 | JAK3 (0.64) | JAK3JAK2LRRK2RETFLT3 | |
| SCHEMBL5728456 | 0.77 | JAK3 (0.63) | JAK3JAK2LRRK2RETFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070167488-A1 | Novel therapeutic use | LEO PHARMA A/S (DK) | 2007-07-19 | — | — | US | claimed |
| EP-1696906-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | Leo Pharma A/S (DK) | 2006-09-06 | — | — | EP | claimed |
| EP-1366038-B1 | CDK-1 INHIBITOR OXINDOLES AND THE APPLICATION THEREOF IN THERAPEUTICS | AVENTIS PHARMA SA (FR) | 2005-08-31 | — | — | EP | claimed |
| WO-2005058309-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | LEO PHARMA A/S (DK) | 2005-06-30 | — | — | WO | claimed |
| US-20040110770-A1 | Oxindoles which are inhibitors of CDK-1 and their application in therapeutics | AVENTIS PHARMA SA (FR) | 2004-06-10 | — | — | US | claimed |
| US-20180153902-A1 | SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION | HOWARD HUGHES MEDICAL INSTITUTE | 2018-06-07 | — | — | US | disclosed |
| US-9782417-B2 | Methods of increasing satellite cell proliferation with kinase inhibitors | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2017-10-10 | — | — | US | disclosed |
| US-20160220580-A1 | SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-08-04 | — | — | US | disclosed |
| US-9248185-B2 | Methods of increasing satellite cell proliferation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-02-02 | — | — | US | disclosed |
| US-20140294855-A1 | SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-10-02 | — | — | US | disclosed |
| US-20070167488-A1 | Novel therapeutic use | LEO PHARMA A/S (DK) | 2007-07-19 | — | — | US | disclosed |
| EP-1696906-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | Leo Pharma A/S (DK) | 2006-09-06 | — | — | EP | disclosed |
| EP-1366038-B1 | CDK-1 INHIBITOR OXINDOLES AND THE APPLICATION THEREOF IN THERAPEUTICS | AVENTIS PHARMA SA (FR) | 2005-08-31 | — | — | EP | disclosed |
| WO-2005058309-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | LEO PHARMA A/S (DK) | 2005-06-30 | — | — | WO | disclosed |
| US-20040110770-A1 | Oxindoles which are inhibitors of CDK-1 and their application in therapeutics | AVENTIS PHARMA SA (FR) | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110770-A1 | Oxindoles which are inhibitors of CDK-1 and their application in therapeutics | CCNI, CCNH, CDK1 | JAK3 249/4885JAK2 302/4885LRRK2 3289/4885 |
| US-20180153902-A1 | SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION | MKI67, MYLK2, MYH2 | JAK3 4267/4885JAK2 4529/4885LRRK2 2584/4885 |
| US-20070167488-A1 | Novel therapeutic use | MAG, PMP22, MYT1 | JAK3 2629/4885JAK2 4245/4885LRRK2 1753/4885 |
| US-20140294855-A1 | SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION | MKI67, MYLK2, MYH2 | JAK3 4231/4885JAK2 4526/4885LRRK2 2579/4885 |
| US-20160220580-A1 | SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION | MKI67, MYLK2, MYH2 | JAK3 4267/4885JAK2 4529/4885LRRK2 2584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.