Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5783672 | 0.91 | PRKCA (0.46) | PRKCAMMP12SCN9ANR1I2PTGES | |
| SCHEMBL5438018 | 0.90 | PRKCA (0.46) | PRKCAMMP12SCN9APTGER4FABP4 | |
| SCHEMBL5465729 | 0.86 | PRKCA (0.39) | PRKCAMMP12SCN9ANR1I2EGLN1 | |
| SCHEMBL14468741 | 0.85 | PRKCA (0.45) | PRKCAMMP12SCN9ANR1I2PTGER4 | |
| SCHEMBL5470483 | 0.84 | SCN9A (0.44) | PRKCAMMP12SCN9ANR1I2EGLN1 | |
| SCHEMBL5817418 | 0.84 | SCN9A (0.53) | PRKCAMMP12SCN9ANR1I2 | |
| SCHEMBL5819417 | 0.82 | PRKCA (0.43) | PRKCAMMP12SCN9ANR1I2PTGES | |
| SCHEMBL2907228 | 0.80 | PRKCA (0.50) | PRKCAMMP12SCN9ANR1I2FABP4 | |
| SCHEMBL5443976 | 0.77 | PRKCA (0.45) | PRKCAMMP12SCN9AEGLN1FABP4 | |
| SCHEMBL5438990 | 0.77 | PRKCA (0.45) | PRKCAMMP12SCN9ANR1I2EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007516158-A | — | — | 2007-06-21 | — | — | JP | claimed |
| EP-1613634-A1 | INDOLE ACETAMIDES AS INHIBITORS OF THE HEPATITIS C VIRUS NS5B POLYMERASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2006-01-11 | — | — | EP | claimed |
| WO-2004087714-A1 | INDOLE ACETAMIDES AS INHIBITORS OF THE HEPATITIS C VIRUS NS5B POLYMERASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2004-10-14 | — | — | WO | claimed |