Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.47 |
| ▸ | PAK4 | O96013 | 4/20 | 0.47 |
| ▸ | PLK4 | O00444 | 2/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 9/20 | 0.45 |
| ▸ | RET | P07949 | 3/20 | 0.44 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4525983 | 1.00 | AURKA (0.47) | AURKAAURKBPAK4PLK4NTRK1 | |
| SCHEMBL4513602 | 0.75 | PAK4 (0.45) | AURKAAURKBPAK4PLK4NTRK1 | |
| SCHEMBL8243146 | 0.75 | PAK4 (0.46) | AURKAAURKBPAK4PLK4NTRK1 | |
| SCHEMBL4524542 | 0.73 | IGF1R (0.50) | AURKAPAK4PLK4PAK1GSK3B | |
| SCHEMBL4524538 | 0.73 | IGF1R (0.50) | AURKAPAK4PLK4PAK1GSK3B | |
| SCHEMBL13633931 | 0.73 | PAK4 (0.52) | AURKAAURKBPAK4PLK4NTRK1 | |
| SCHEMBL4515170 | 0.73 | PAK4 (0.44) | AURKAAURKBPAK4PLK4NTRK1 | |
| SCHEMBL10267511 | 0.72 | AURKA (0.53) | AURKAAURKBPAK4PLK4NTRK1 | |
| SCHEMBL4529635 | 0.72 | PAK4 (0.42) | AURKAAURKBPAK4PLK4NTRK1 | |
| SCHEMBL5316477 | 0.72 | NTRK1 (0.47) | PAK4PLK4NTRK1PAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831216-A2 | HETEROAROMATIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006067614-A2 | HETEROAROMATIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2006-06-29 | — | — | WO | disclosed |