Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 3/20 | 0.46 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | SPAST | Q9UBP0 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 8/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.42 |
| ▸ | TYK2 | P29597 | 3/20 | 0.42 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 4/20 | 0.41 |
| ▸ | GSK3B | P49841 | 4/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4524542 | 0.81 | IGF1R (0.50) | PAK4PAK1PLK4AURKATYK2 | |
| SCHEMBL4524538 | 0.81 | IGF1R (0.50) | PAK4PAK1PLK4AURKATYK2 | |
| SCHEMBL10267511 | 0.77 | AURKA (0.53) | PAK4PLK4AURKAAURKBSRC | |
| SCHEMBL30227668 | 0.75 | PLK4 (0.62) | PAK4PLK4AURKAAURKBSRC | |
| SCHEMBL802876 | 0.75 | PLK4 (0.62) | PAK4PLK4AURKAAURKBSRC | |
| SCHEMBL23889479 | 0.75 | PLK4 (0.50) | PAK4PLK4AURKATYK2JAK3 | |
| SCHEMBL13633931 | 0.75 | PAK4 (0.52) | PAK4PAK1PLK4AURKAAURKB | |
| SCHEMBL4513602 | 0.75 | PAK4 (0.45) | PAK4PAK1PLK4AURKAAURKB | |
| SCHEMBL22072741 | 0.75 | SPAST (0.76) | PAK4PAK1PLK4SPASTIGF1R | |
| SCHEMBL4525983 | 0.75 | AURKA (0.47) | PAK4PAK1PLK4AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931322-B1 | IKK INHIBITORS FOR THE TREATMENT OF ENDOMETRIOSIS | MERCK SERONO SA (CH) | 2012-08-15 | — | — | EP | disclosed |
| EP-2266561-A2 | IKK Inhibitors for the Treatment of Endometriosis | Merck Serono S.A. (CH) | 2010-12-29 | — | — | EP | disclosed |
| US-20100069387-A1 | IKK Inhibitors for the Treatment of Endometriosis | MERCK SERONO SA (CH) | 2010-03-18 | — | — | US | disclosed |
| US-20100069387-A1 | IKK Inhibitors for the Treatment of Endometriosis | MERCK SERONO SA (CH) | 2010-03-18 | — | — | US | disclosed |
| WO-2007030362-A1 | IKK INHIBITORS FOR THE TREATMENT OF ENDOMETRIOSIS | LABORATOIRES SERONO SA. (CH) | 2007-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069387-A1 | IKK Inhibitors for the Treatment of Endometriosis | NFKBIA, IKBKG, IKBKE | PAK4 2053/4885PAK1 1343/4885PLK4 987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.