Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29229957 | 0.80 | TDP1 (0.69) | TDP1ALDH1A1MAPTSMN1; SMN2TSHR | |
| SCHEMBL4718853 | 0.79 | TDP1 (0.58) | TDP1ALDH1A1MAPTSMN1; SMN2TSHR | |
| SCHEMBL9049414 | 0.78 | TDP1 (0.53) | TDP1ALDH1A1MAPTSMN1; SMN2TSHR | |
| SCHEMBL641410 | 0.78 | MAPT (0.46) | TDP1ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL4224390 | 0.75 | TSHR (0.50) | TDP1ALDH1A1MAPTSMN1; SMN2TSHR | |
| SCHEMBL24167927 | 0.75 | MAPT (0.49) | ALDH1A1MAPTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL257933 | 0.73 | LMNA (0.54) | ALDH1A1MAPTSMN1; SMN2TSHRKDM4E | |
| SCHEMBL177869 | 0.73 | HTT (0.58) | ALDH1A1MAPTSMN1; SMN2LMNANPC1 | |
| SCHEMBL29888161 | 0.72 | MEN1 (0.53) | TDP1ALDH1A1MAPTTSHRKDM4E | |
| SCHEMBL216106 | 0.72 | MEN1 (0.53) | TDP1ALDH1A1MAPTTSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070015743-A1 | Quinazoline derivatives as antitumor agents | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015743-A1 | Quinazoline derivatives as antitumor agents | ERBB2, ABL1, EGFR | TDP1 2695/4885ALDH1A1 2621/4885MAPT 3525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.