Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.61 |
| ▸ | SYK | P43405 | 18/20 | 0.58 |
| ▸ | CD63 | P08962 | 2/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.57 |
| ▸ | ROS1 | P08922 | 1/20 | 0.57 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.57 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.57 |
| ▸ | BTK | Q06187 | 1/20 | 0.57 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.57 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2482275 | 0.85 | AURKA (0.79) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL5479137 | 0.83 | AURKA (0.59) | AURKASYKBTK | |
| SCHEMBL27306130 | 0.81 | SYK (0.60) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL3422119 | 0.81 | SYK (0.86) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL19998666 | 0.80 | AURKA (0.53) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL23911850 | 0.80 | AURKA (0.81) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL2480971 | 0.80 | SYK (0.87) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL6517337 | 0.78 | AURKA (0.55) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL5478244 | 0.77 | AURKA (0.56) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL2481450 | 0.77 | AURKA (0.69) | AURKASYKCD63JAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312341-B2 | 6-aryl-imidazo[1,2-a] pyrazin-8-ylamines, method of making, and method of use thereof | CGI PHARMACEUTICALS, INC. (US) | 2007-12-25 | — | — | US | claimed |