Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.56 |
| ▸ | SYK | P43405 | 14/20 | 0.47 |
| ▸ | CD63 | P08962 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | ROS1 | P08922 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.41 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6517337 | 0.79 | AURKA (0.55) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL5478247 | 0.77 | AURKA (0.61) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL5479137 | 0.74 | AURKA (0.59) | AURKASYKBTK | |
| SCHEMBL2478983 | 0.71 | SYK (0.75) | SYKCD63 | |
| SCHEMBL4766448 | 0.69 | TAAR1 (0.41) | — | |
| SCHEMBL2482275 | 0.68 | AURKA (0.79) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL13337418 | 0.68 | SYK (0.64) | AURKASYKCD63 | |
| SCHEMBL5478486 | 0.67 | AURKA (0.78) | AURKASYKBTK | |
| SCHEMBL5482196 | 0.66 | AURKA (0.79) | AURKASYKBTK | |
| SCHEMBL13764320 | 0.65 | RAB9A (0.59) | AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312341-B2 | 6-aryl-imidazo[1,2-a] pyrazin-8-ylamines, method of making, and method of use thereof | CGI PHARMACEUTICALS, INC. (US) | 2007-12-25 | — | — | US | claimed |