Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4448757 | 0.88 | MAPT (0.57) | MAPTSMN1; SMN2POLBALDH1A1MEN1 | |
| SCHEMBL5456801 | 0.81 | ABCG2 (0.51) | MAPTSMN1; SMN2ALDH1A1MAPK1NPC1 | |
| SCHEMBL4409525 | 0.80 | TSHR (0.61) | MAPTSMN1; SMN2POLBALDH1A1NPC1 | |
| SCHEMBL5478341 | 0.77 | MAPT (0.48) | MAPTSMN1; SMN2POLBALDH1A1MAPK1 | |
| SCHEMBL5466423 | 0.75 | ALDH1A1 (0.56) | MAPTSMN1; SMN2POLBALDH1A1MAPK1 | |
| SCHEMBL1015345 | 0.75 | CA12 (0.73) | MAPTSMN1; SMN2ALDH1A1MAPK1NPC1 | |
| SCHEMBL16956653 | 0.75 | ALDH1A1 (0.50) | MAPTSMN1; SMN2POLBALDH1A1MAPK1 | |
| SCHEMBL24812339 | 0.74 | MAPK1 (0.62) | MAPTSMN1; SMN2POLBALDH1A1MAPK1 | |
| SCHEMBL6568018 | 0.74 | MAPT (0.66) | MAPTSMN1; SMN2ALDH1A1MAPK1NPC1 | |
| SCHEMBL25139437 | 0.74 | HIF1A (0.53) | MAPTSMN1; SMN2ALDH1A1MAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070032477-A1 | Pteridine derivatives useful for making pharmaceutical compositions | 4 AZA BIOSCIENCE NV (BE) | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032477-A1 | Pteridine derivatives useful for making pharmaceutical compositions | TPMT, TYMS, TNF | MAPT 919/4885SMN1; SMN2 1061/4885POLB 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.