Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethylketone Cyanohydrin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HMGCR | P04035 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylketone Cyanohydrin SCHEMBL11460654 | 0.90 | FFAR3 (0.44) | ALDH1A1TSHRHMGCRCHRM1TBXA2R | |
| Dimethylketone Cyanohydrin SCHEMBL6474504 | 0.87 | LMNA (0.40) | ALDH1A1TSHRHMGCRCHRM1TBXA2R | |
| Dimethylketone Cyanohydrin SCHEMBL27317753 | 0.86 | TDP1 (0.38) | ALDH1A1TSHRCA1CA2CA9 | |
| Dimethylketone Cyanohydrin SCHEMBL29665840 | 0.86 | — | — | |
| Dimethylketone Cyanohydrin SCHEMBL34145 | 0.86 | — | — | |
| Dimethylketone Cyanohydrin SCHEMBL27982437 | 0.82 | — | — | |
| Dimethylketone Cyanohydrin SCHEMBL27743725 | 0.82 | — | — | |
| Dimethylketone Cyanohydrin SCHEMBL22127954 | 0.81 | LMNA (0.35) | ALDH1A1TSHRTDP1 | |
| Dimethylketone Cyanohydrin SCHEMBL27825354 | 0.80 | — | — | |
| Dimethylketone Cyanohydrin SCHEMBL16177662 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130041056-A1 | POLYMETHACRYLIMIDE FOAM MATERIALS HAVING REDUCED FLAMMABILITY AND METHOD FOR PRODUCING SAME | EVONIK ROEHM GMBH (DE) | 2013-02-14 | — | — | US | claimed |
| US-20240026109-A1 | ADHESION OF BLOWING AGENT-CONTAINING PARTICLES BASED ON POLYIMIDES OR POLYACRYLATES | EVONIK OPERATIONS GMBH (DE) | 2024-01-25 | — | — | US | disclosed |
| EP-4255970-A1 | ADHESION OF BLOWING AGENT-CONTAINING PARTICLES BASED ON POLYIMIDES OR POLYACRYLATES | Evonik Operations GmbH (DE) | 2023-10-11 | — | — | EP | disclosed |
| CN-116457399-A | Adhesion of particles containing foaming agent based on polyimide or polyacrylate | 赢创运营有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022117331-A1 | ADHESION OF BLOWING AGENT-CONTAINING PARTICLES BASED ON POLYIMIDES OR POLYACRYLATES | EVONIK OPERATIONS GMBH (DE) | 2022-06-09 | — | — | WO | disclosed |
| EP-3978215-A1 | PRODUCTION OF COMPLEX FOAM MOULDS WITH CLASS-A CAPABLE SURFACES | Evonik Operations GmbH (DE) | 2022-04-06 | — | — | EP | disclosed |
| CN-108026308-B | Polyfunctional alcohols as crosslinkers in PMI foams | 赢创运营有限公司 | 2021-10-01 | — | — | CN | disclosed |
| US-10619024-B2 | Polyfunctional alcohols as cross-linkers in PMI foams | EVONIK OPERATIONS GMBH (DE) | 2020-04-14 | — | — | US | disclosed |
| US-20190153186-A1 | POLYFUNCTIONAL ALCOHOLS AS CROSS-LINKERS IN PMI FOAMS | EVONIK ROEHM GMBH (DE) | 2019-05-23 | — | — | US | disclosed |
| US-9260599-B2 | Process for preparing expanded copolymers based on poly(meth)acrylimide comprising an adhesion promoter | EVONIK ROEHM GMBH (DE) | 2016-02-16 | — | — | US | disclosed |
| US-9212269-B2 | PMI foams with improved mechanical properties, in particular with increased elongation at tear | EVONIK ROEHM GMBH (DE) | 2015-12-15 | — | — | US | disclosed |
| US-20140309361-A1 | PROCESS FOR PREPARING EXPANDED COPOLYMERS BASED ON POLY(METH)ACRYLIMIDE COMPRISING AN ADHESION PROMOTER | EVONIK ROEHM GMBH (DE) | 2014-10-16 | — | — | US | disclosed |
| US-8722751-B2 | Thermostable microporous polymethacrylimide foams | EVONIK ROHM GMBH (DE) | 2014-05-13 | — | — | US | disclosed |
| US-20130108817-A1 | PMI FOAMS WITH IMPROVED MECHANICAL PROPERTIES, IN PARTICULAR WITH INCREASED ELONGATION AT TEAR | EVONIK ROEHM GMBH (DE) | 2013-05-02 | — | — | US | disclosed |
| US-20130041056-A1 | POLYMETHACRYLIMIDE FOAM MATERIALS HAVING REDUCED FLAMMABILITY AND METHOD FOR PRODUCING SAME | EVONIK ROEHM GMBH (DE) | 2013-02-14 | — | — | US | disclosed |
| US-20070077442-A1 | Thermostable microporous polymethacrylimide foams | ROEHM GMBH (DE) | 2007-04-05 | — | — | US | disclosed |