Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 3/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.36 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4717317 | 1.00 | PDE3A (0.43) | PDE3AHCRTR1HCRTR2CCNCCDK8 | |
| SCHEMBL14341441 | 1.00 | PDE3A (0.43) | PDE3AHCRTR1HCRTR2CCNCCDK8 | |
| SCHEMBL14341442 | 0.84 | EHMT2 (0.51) | PDE3AHCRTR1HCRTR2CCNCCDK8 | |
| SCHEMBL4717969 | 0.84 | EHMT2 (0.51) | PDE3AHCRTR1HCRTR2CCNCCDK8 | |
| SCHEMBL4164651 | 0.84 | PDE10A (0.46) | PDE3AHCRTR1HCRTR2CCNCCDK8 | |
| SCHEMBL4791600 | 0.84 | PDE10A (0.46) | PDE3AHCRTR1HCRTR2CCNCCDK8 | |
| SCHEMBL5651013 | 0.83 | PDE3A (0.60) | PDE3AENPP1PDE3BPDE10A | |
| SCHEMBL8235019 | 0.83 | KDM4E (0.44) | PDE3AHCRTR1HCRTR2ENPP1PDE10A | |
| SCHEMBL5479465 | 0.80 | HCRTR1 (0.39) | HCRTR1HCRTR2DPP4 | |
| SCHEMBL5653291 | 0.74 | PDE10A (0.46) | PDE3AENPP1PDE10AEHMT2EHMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070299067-A1 | Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors | AMGEN INC. | 2007-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299067-A1 | Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors | PDE12, PDE10A, PDE4A | PDE3A 11/4885HCRTR1 1197/4885HCRTR2 1699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.