Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 9/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 10/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8234967 | 0.86 | EHMT2 (0.51) | HTR7PDE3AHTR1APRKDCPDE10A | |
| SCHEMBL4717317 | 0.83 | PDE3A (0.43) | HCRTR1HCRTR2PDE3APDE10AENPP1 | |
| SCHEMBL5479463 | 0.83 | PDE3A (0.43) | HCRTR1HCRTR2PDE3APDE10AENPP1 | |
| SCHEMBL14341441 | 0.83 | PDE3A (0.43) | HCRTR1HCRTR2PDE3APDE10AENPP1 | |
| SCHEMBL4975444 | 0.74 | PDE10A (0.43) | KDM4EPOLBMAPTL3MBTL1HTR7 | |
| SCHEMBL5479465 | 0.73 | HCRTR1 (0.39) | KDM4EHCRTR1HCRTR2 | |
| SCHEMBL4778173 | 0.70 | KIT (0.40) | PDE3APDE10A | |
| SCHEMBL27691688 | 0.69 | HTR1A (0.49) | KDM4EPOLBMAPTL3MBTL1HTR1A | |
| SCHEMBL22396575 | 0.68 | IRAK4 (0.52) | — | |
| SCHEMBL22396619 | 0.68 | IRAK4 (0.52) | ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007103554-A1 | QUINOLINE AND ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2007-09-13 | — | — | WO | disclosed |