Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 11/20 | 0.38 |
| ▸ | CTSS | P25774 | 10/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23009823 | 0.87 | KMT2A (0.39) | CTSKMEN1KMT2AGAAMAPT | |
| SCHEMBL16412190 | 0.85 | USP2 (0.47) | MEN1KMT2AGAAALDH1A1MAPT | |
| SCHEMBL8490442 | 0.80 | ZDHHC7 (0.46) | MAPT | |
| SCHEMBL7370423 | 0.80 | TDP1 (0.49) | MEN1KMT2AGAATDP1 | |
| SCHEMBL17377641 | 0.80 | ZDHHC7 (0.46) | MAPT | |
| SCHEMBL28669106 | 0.79 | USP2 (0.44) | CTSKCTSSMEN1KMT2AGAA | |
| SCHEMBL9321291 | 0.79 | TDP1 (0.45) | MEN1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL16543607 | 0.79 | MEN1 (0.34) | CTSKMEN1KMT2AGAATDP1 | |
| SCHEMBL21202161 | 0.78 | CTSS (0.32) | CTSKCTSSMEN1KMT2A | |
| SCHEMBL21202146 | 0.78 | CTSS (0.32) | CTSKCTSSMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110577-B2 | Histone deacetylase inhibitors | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2012-02-07 | — | — | US | disclosed |
| US-8110577-B2 | Histone deacetylase inhibitors | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2012-02-07 | — | — | US | disclosed |
| US-8110577-B2 | Histone deacetylase inhibitors | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2012-02-07 | — | — | US | disclosed |
| US-20100160392-A1 | HISTONE DEACETYLASE INHIBITORS | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2010-06-24 | — | — | US | disclosed |
| US-20100160392-A1 | HISTONE DEACETYLASE INHIBITORS | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2010-06-24 | — | — | US | disclosed |
| US-20100160392-A1 | HISTONE DEACETYLASE INHIBITORS | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2010-06-24 | — | — | US | disclosed |
| EP-2086950-A2 | HISTONE DEACETYLASE INHIBITORS | Queen Mary and Westfield College (GB) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008047138-A2 | HISTONE DEACETYLASE INHIBITORS | QUEEN MARY AND WESTFIELD COLLEGE (GB) | 2008-04-24 | — | — | WO | disclosed |
| WO-2008047138-A2 | HISTONE DEACETYLASE INHIBITORS | QUEEN MARY AND WESTFIELD COLLEGE (GB) | 2008-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160392-A1 | HISTONE DEACETYLASE INHIBITORS | HDAC3, HDAC1, HDAC4 | CTSK 3813/4885CTSS 2241/4885MEN1 4680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.