Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | HTR1B | P28222 | 10/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | OGG1 | O15527 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14432532 | 0.84 | KDM4E (0.52) | ALDH1A1KDM4EHSD17B10HTR1BHTR1D | |
| SCHEMBL2561039 | 0.84 | HTR1B (0.44) | ALDH1A1KDM4EHSD17B10HTR1BHTR1D | |
| SCHEMBL5120304 | 0.80 | TAAR1 (0.39) | ALDH1A1KDM4ETDP1 | |
| SCHEMBL4258447 | 0.80 | TAAR1 (0.39) | ALDH1A1KDM4ETDP1 | |
| SCHEMBL5318577 | 0.80 | SLC6A4 (0.46) | ALDH1A1KDM4EHSD17B10HTR1BHTR1D | |
| SCHEMBL1535358 | 0.80 | SLC6A4 (0.46) | ALDH1A1KDM4EHSD17B10HTR1BHTR1D | |
| Hydrochloric Acid SCHEMBL4730956 | 0.79 | SMN1; SMN2 (0.39) | ALDH1A1KDM4EHPGDTDP1MAPK1 | |
| Hydrochloric Acid SCHEMBL4053969 | 0.79 | SLC6A4 (0.45) | ALDH1A1KDM4EHSD17B10HTR1BHTR1D | |
| SCHEMBL6563061 | 0.77 | TAAR1 (0.36) | KDM4EHSD17B10SLC6A4HPGDTDP1 | |
| SCHEMBL5527328 | 0.76 | TAAR1 (0.44) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1746985-A2 | METHOD FOR AUGMENTING THE EFFECTS OF SEROTONIN REUPTAKE INHIBITORS | DUKE UNIVERSITY (US) | 2007-01-31 | — | — | EP | disclosed |
| WO-2005112906-A2 | METHOD FOR AUGMENTING THE EFFECTS OF SEROTONIN REUPTAKE INHIBITORS | DUKE UNIVERSITY (US) | 2005-12-01 | — | — | WO | disclosed |