Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 10/20 | 0.56 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CIT | O14578 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL549150 | 0.89 | RAF1 (0.56) | RAF1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL549118 | 0.89 | RAF1 (0.65) | RAF1KDRMEN1KMT2AMAPT | |
| SCHEMBL548196 | 0.87 | RAF1 (0.55) | RAF1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL2478377 | 0.80 | RAF1 (0.86) | RAF1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL29733289 | 0.78 | RAF1 (0.67) | RAF1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL548256 | 0.78 | RAF1 (0.67) | RAF1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL14481108 | 0.76 | RAF1 (0.60) | RAF1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL548163 | 0.76 | RAF1 (0.64) | RAF1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL14680565 | 0.75 | RAF1 (0.56) | RAF1KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL29523346 | 0.74 | KDR (0.59) | RAF1KDRHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9181188-B2 | Aryl ureas as kinase inhibitors | BAYER HEALTHCARE LLC (US) | 2015-11-10 | — | — | US | claimed |
| US-20120136157-A1 | ARYL UREAS AS KINASE INHIBITORS | DUMAS JACQUES (US) | 2012-05-31 | — | — | US | claimed |
| EP-1580188-B9 | Aryl ureas as kinase inhibitors | BAYER HEALTHCARE LLC (US) | 2012-05-23 | — | — | EP | claimed |
| US-8110587-B2 | Antiinflammatory agents; anticancer agents; osteoporosis | BAYER HEALTHCARE LLC (US) | 2012-02-07 | — | — | US | claimed |
| EP-1580188-B1 | Aryl ureas as kinase inhibitors | BAYER HEALTHCARE LLC (US) | 2011-10-19 | — | — | EP | claimed |
| JP-4527401-B2 | — | — | 2010-08-18 | — | — | JP | claimed |
| EP-1580188-A1 | Aryl ureas as kinase inhibitors | Bayer Pharmaceuticals Corporation (US) | 2005-09-28 | — | — | EP | claimed |
| JP-2005523278-A | — | — | 2005-08-04 | — | — | JP | claimed |
| EP-1474393-A1 | ARYL UREAS AS KINASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-11-10 | — | — | EP | claimed |
| US-20030216446-A1 | Aryl ureas as kinase inhibitors | BAYER CORPORATION (US) | 2003-11-20 | — | — | US | claimed |
| WO-2003068746-A1 | ARYL UREAS AS KINASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-08-21 | — | — | WO | claimed |
| US-9181188-B2 | Aryl ureas as kinase inhibitors | BAYER HEALTHCARE LLC (US) | 2015-11-10 | — | — | US | disclosed |
| US-20120136157-A1 | ARYL UREAS AS KINASE INHIBITORS | DUMAS JACQUES (US) | 2012-05-31 | — | — | US | disclosed |
| EP-1580188-B9 | Aryl ureas as kinase inhibitors | BAYER HEALTHCARE LLC (US) | 2012-05-23 | — | — | EP | disclosed |
| US-8110587-B2 | Antiinflammatory agents; anticancer agents; osteoporosis | BAYER HEALTHCARE LLC (US) | 2012-02-07 | — | — | US | disclosed |
| EP-1580188-B1 | Aryl ureas as kinase inhibitors | BAYER HEALTHCARE LLC (US) | 2011-10-19 | — | — | EP | disclosed |
| EP-1580188-A1 | Aryl ureas as kinase inhibitors | Bayer Pharmaceuticals Corporation (US) | 2005-09-28 | — | — | EP | disclosed |
| US-20030216446-A1 | Aryl ureas as kinase inhibitors | BAYER CORPORATION (US) | 2003-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216446-A1 | Aryl ureas as kinase inhibitors | MAPK1, MAP3K1, MAP3K6 | RAF1 47/4885KDR 40/4885HDAC3 2924/4885 |
| US-20120136157-A1 | ARYL UREAS AS KINASE INHIBITORS | MAPK1, MAP3K1, MAP3K6 | RAF1 47/4885KDR 40/4885HDAC3 2924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.