Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CASR | P41180 | 8/20 | 0.43 |
| ▸ | GNRHR | P30968 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5411840 | 0.93 | CASR (0.43) | POLBCASRGNRHRRXFP1CHRM1 | |
| SCHEMBL5460001 | 0.86 | MEN1 (0.42) | CASRGNRHRMEN1KMT2A | |
| SCHEMBL5362360 | 0.84 | CASR (0.48) | CASRGNRHRMEN1KMT2A | |
| SCHEMBL5477121 | 0.83 | CASR (0.47) | CASRGNRHRMEN1KMT2A | |
| SCHEMBL5429119 | 0.83 | CASR (0.42) | POLBCASRSMN1; SMN2MAPTHPGD | |
| SCHEMBL5419037 | 0.82 | CASR (0.38) | POLBCASRSMN1; SMN2MAPTHPGD | |
| SCHEMBL5310323 | 0.81 | CASR (0.52) | POLBCASRRXFP1SMN1; SMN2MAPT | |
| SCHEMBL5415146 | 0.80 | CASR (0.37) | CASRGNRHRMAPTHTT | |
| SCHEMBL5425459 | 0.77 | CASR (0.43) | POLBCASRGNRHRMEN1KMT2A | |
| SCHEMBL5312353 | 0.76 | CASR (0.54) | POLBCASRRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |