Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 13/20 | 0.43 |
| ▸ | GNRHR | P30968 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CHRNE | Q04844 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5362360 | 0.90 | CASR (0.48) | CASRGNRHRMEN1KMT2A | |
| SCHEMBL5477121 | 0.84 | CASR (0.47) | CASRGNRHRMEN1KMT2A | |
| SCHEMBL5310935 | 0.81 | CASR (0.48) | CASRPOLB | |
| SCHEMBL5413917 | 0.78 | CASR (0.36) | CASRGNRHRMEN1KMT2A | |
| SCHEMBL5411840 | 0.77 | CASR (0.43) | CASRGNRHRPOLB | |
| SCHEMBL5481284 | 0.77 | POLB (0.45) | CASRGNRHRMEN1KMT2APOLB | |
| SCHEMBL5460001 | 0.73 | MEN1 (0.42) | CASRGNRHRMEN1KMT2ACHRNE | |
| SCHEMBL5429119 | 0.73 | CASR (0.42) | CASRPOLB | |
| SCHEMBL5308386 | 0.72 | CASR (0.54) | CASR | |
| SCHEMBL5419037 | 0.70 | CASR (0.38) | CASRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |