Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 13/20 | 0.76 |
| ▸ | DRD2 | P14416 | 4/20 | 0.76 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.76 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.76 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.76 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.76 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.76 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.76 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.76 |
| ▸ | HTR2C | P28335 | 1/20 | 0.76 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.66 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.61 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.61 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.59 |
| ▸ | DRD1 | P21728 | 1/20 | 0.59 |
| ▸ | DRD4 | P21917 | 1/20 | 0.59 |
| ▸ | HTR7 | P34969 | 1/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.59 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5480017 | 0.87 | CHRM1 (0.82) | CHRM1DRD2CHRM2CHRM4CHRM3 | |
| SCHEMBL5473311 | 0.86 | CHRM1 (1.00) | CHRM1DRD2CHRM2CHRM4CHRM3 | |
| SCHEMBL30558524 | 0.86 | CHRM1 (1.00) | CHRM1DRD2CHRM2CHRM4CHRM3 | |
| SCHEMBL5478062 | 0.84 | CHRM1 (0.77) | CHRM1DRD2CHRM2CHRM4CHRM3 | |
| SCHEMBL5469929 | 0.84 | CHRM1 (0.77) | CHRM1DRD2CHRM2CHRM4CHRM3 | |
| SCHEMBL5475048 | 0.84 | CHRM1 (0.77) | CHRM1DRD2CHRM2CHRM4CHRM3 | |
| SCHEMBL5476466 | 0.84 | CHRM1 (1.00) | CHRM1DRD2CHRM2CHRM4CHRM3 | |
| SCHEMBL5482251 | 0.84 | CHRM1 (0.76) | CHRM1DRD2CHRM2CHRM4CHRM3 | |
| SCHEMBL5486679 | 0.82 | CHRM1 (1.00) | CHRM1DRD2CHRM2CHRM4CHRM3 | |
| SCHEMBL8863557 | 0.82 | OPRM1 (0.91) | CHRM1DRD2CHRM2CHRM4CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515722-A4 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO INC (US) | 2006-06-21 | — | — | EP | claimed |
| US-20050176765-A1 | Ophthalmic compositions for treating ocular hypertension | MSD K.K. (JP) | 2005-08-11 | — | — | US | claimed |
| EP-1515722-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2005-03-23 | — | — | EP | claimed |
| WO-2003105781-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2003-12-24 | — | — | WO | claimed |
| US-7279490-B2 | Ophthalmic compositions for treating ocular hypertension | MERCK & CO, INC. (US) | 2007-10-09 | — | — | US | disclosed |
| US-7279490-B2 | Ophthalmic compositions for treating ocular hypertension | MERCK & CO, INC. (US) | 2007-10-09 | — | — | US | disclosed |
| US-7279490-B2 | Ophthalmic compositions for treating ocular hypertension | MERCK & CO, INC. (US) | 2007-10-09 | — | — | US | disclosed |
| US-20050176765-A1 | Ophthalmic compositions for treating ocular hypertension | MSD K.K. (JP) | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176765-A1 | Ophthalmic compositions for treating ocular hypertension | CHRM1, CHRM2, CHRM5 | CHRM1 1/4885DRD2 75/4885CHRM2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.