Tryptophan

Tryptophan

SCHEMBL5481922

CC(O)[C@H](N)C(=O)O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O

nearest known ligand 0.80

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.80
MAPT P10636 3/20 0.80
KMT2A Q03164 3/20 0.80
LMNA P02545 2/20 0.80
TSHR P16473 2/20 0.80
BLM P54132 2/20 0.80
PMP22 Q01453 2/20 0.80
MEN1 O00255 2/20 0.80
MPO P05164 1/20 0.80
HIF1A Q16665 1/20 0.80
APAF1 O14727 1/20 0.64
POLB P06746 1/20 0.64
RECQL P46063 1/20 0.64
L3MBTL1 Q9Y468 1/20 0.64
SMN1; SMN2 Q16637 1/20 0.61
HTR2A P28223 3/20 0.58
HTR1A P08908 2/20 0.58
HTR2C P28335 2/20 0.58
SLC6A4 P31645 2/20 0.58
HTR7 P34969 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tryptophan SCHEMBL6268677 1.00 KDM4E (0.80) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL537140 1.00 KDM4E (0.80) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL27147785 1.00 KDM4E (0.80) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL12497478 1.00 KDM4E (0.80) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL537138 1.00 KDM4E (0.80) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL12497474 1.00 KDM4E (0.80) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL11217425 1.00 KDM4E (0.80) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL28120361 0.98 KDM4E (0.76) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL7154073 0.96 KDM4E (0.74) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL7859113 0.96 KDM4E (0.74) KDM4EMAPTKMT2ALMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117279506-A Tumor storage and cell culture compositions 艾欧凡斯生物治疗公司 2023-12-22 CN disclosed
US-20150301067-A1 METHODS AND ASSAYS FOR FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) 2015-10-22 US disclosed
WO-2014071340-A1 METHODS AND ASSAYS FOR FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) 2014-05-08 WO disclosed
US-20070141681-A1 Process for the production of L-amino acids using strains of the Enterobacteriaceae family DEGUSSA AG (DE) 2007-06-21 US disclosed
US-7211415-B2 Enterobacteriaceae strains over-expressing the yfiD gene for the fermentative production of L-amino acids DEGUSSA AG (DE) 2007-05-01 US disclosed
US-20040235122-A1 Process for the production of L-amino acids using strains of the enterobacteriaceae family EVONIK OPERATIONS GMBH (DE) 2004-11-25 US disclosed
US-4211795-A Animal feeds Institut National de la Recherche Agronomique and Aussedat-Rey (FR) 1980-07-08 US disclosed