Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 15/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4829859 | 0.87 | IGF1R (0.44) | IGF1R | |
| SCHEMBL5069055 | 0.71 | NEK1 (0.38) | IGF1RSRCGSK3BAURKB | |
| SCHEMBL12430994 | 0.70 | PAK4 (0.46) | IGF1RSRCGSK3B | |
| SCHEMBL13054674 | 0.69 | IGF1R (0.45) | IGF1RSRCGSK3BAURKBAURKA | |
| SCHEMBL5481449 | 0.69 | AURKA (0.54) | SRCGSK3BAURKBAURKANTRK1 | |
| SCHEMBL12430984 | 0.69 | GSK3B (0.45) | IGF1RSRCGSK3BAURKBNTRK1 | |
| SCHEMBL12430855 | 0.68 | AURKB (0.59) | IGF1RSRCGSK3BAURKBAURKA | |
| SCHEMBL4959505 | 0.68 | IGF1R (0.66) | IGF1R | |
| SCHEMBL10294900 | 0.65 | ULK1 (0.50) | IGF1RSRCGSK3BAURKBAURKA | |
| SCHEMBL5958903 | 0.65 | IGF1R (0.43) | IGF1RSRCGSK3BAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345928-B1 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2007-02-14 | — | — | EP | claimed |
| US-20040167141-A1 | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED | 2004-08-26 | — | — | US | claimed |
| JP-2004516292-A | — | — | 2004-06-03 | — | — | JP | claimed |
| EP-1345928-A2 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2003-09-24 | — | — | EP | claimed |
| US-20030022885-A1 | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED | 2003-01-30 | — | — | US | claimed |
| WO-2002050066-A2 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2002-06-27 | — | — | WO | claimed |
| US-20140187772-A1 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2014-07-03 | — | — | US | disclosed |
| US-20130096128-A1 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2013-04-18 | — | — | US | disclosed |
| US-8304414-B2 | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-11-06 | — | — | US | disclosed |
| US-20080287444-A1 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2008-11-20 | — | — | US | disclosed |
| US-7427681-B2 | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167141-A1 | Pyrazole compounds useful as protein kinase inhibitors | AURKC, AURKA, GSK3B | IGF1R 1037/4885SRC 369/4885GSK3B 3/4885 |
| US-20030022885-A1 | Pyrazole compounds useful as protein kinase inhibitors | AURKC, AURKA, GSK3B | IGF1R 1037/4885SRC 369/4885GSK3B 3/4885 |
| US-20130096128-A1 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | AURKC, AURKA, CDK3 | IGF1R 781/4885SRC 429/4885GSK3B 4/4885 |
| US-20140187772-A1 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | AURKC, AURKA, CDK3 | IGF1R 781/4885SRC 429/4885GSK3B 4/4885 |
| US-20080287444-A1 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | AURKC, AURKA, CDK3 | IGF1R 781/4885SRC 429/4885GSK3B 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.