SCHEMBL5482121

SCHEMBL5482121

CCOC(=O)C(C)(C)Oc1c(C)cc(CN(Cc2nc(-c3ccccc3)no2)Cc2ncc(C)o2)cc1C

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 2/20 0.43
PPARG P37231 1/20 0.43
TSHR P16473 10/20 0.42
TP53 P04637 1/20 0.42
ALOX15 P16050 1/20 0.41
ALDH1A1 P00352 6/20 0.40
MAPT P10636 1/20 0.40
MAPK1 P28482 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
KMT2A Q03164 3/20 0.39
HTT P42858 2/20 0.39
MEN1 O00255 1/20 0.38
GAA P10253 1/20 0.38
LMNA P02545 1/20 0.38
HPGD P15428 1/20 0.38
ATM Q13315 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5475620 0.92 PPARA (0.51) PPARAPPARGTSHRTP53ALOX15
SCHEMBL5484176 0.88 PPARA (0.44) PPARAPPARG
SCHEMBL5472709 0.86 TSHR (0.41) PPARAPPARGTSHRTP53ALOX15
SCHEMBL14414971 0.79 PPARA (0.46) PPARAPPARG
SCHEMBL5473393 0.79 PPARA (0.53) PPARAPPARG
SCHEMBL5480642 0.79 PPARA (0.62) PPARAPPARG
SCHEMBL5480406 0.78 PPARA (0.49) PPARAPPARGTSHRTP53ALOX15
SCHEMBL5480236 0.77 PPARA (0.42) PPARAPPARG
SCHEMBL5477561 0.76 MAPT (0.47) PPARAPPARGTSHRTP53ALDH1A1
SCHEMBL5481222 0.76 PPARG (0.47) PPARAPPARGALDH1A1KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same DAIICHI PHARMACEUTICAL CO., LTD. 2007-09-06 US disclosed
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same DAIICHI PHARMACEUTICAL CO., LTD. 2007-09-06 US disclosed
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same DAIICHI PHARMACEUTICAL CO., LTD. 2007-09-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same PPARA, PPARG, PPARD PPARA 1/4885PPARG 2/4885TSHR 176/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.