SCHEMBL5482507

SCHEMBL5482507

COCCc1ncc2[nH]cnc2n1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.47
KDM4E B2RXH2 1/20 0.47
POLA1 P09884 1/20 0.40
CDK2 P24941 4/20 0.39
RXFP1 Q9HBX9 1/20 0.39
PAK1 Q13153 1/20 0.37
LMNA P02545 1/20 0.37
HTT P42858 1/20 0.37
ADORA3 P0DMS8 1/20 0.35
IP6K1 Q92551 7/20 0.34
CDK1 P06493 3/20 0.33
CCNB1 P14635 3/20 0.33
CCNT1 O60563 1/20 0.33
CDK7 P50613 1/20 0.33
CDK9 P50750 1/20 0.33
CCNH P51946 1/20 0.33
AGTR1 P30556 1/20 0.32
AGTR2 P50052 1/20 0.32
CCNA2 P20248 2/20 0.32
CCNA1 P78396 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11077322 0.83 ALDH1A1 (0.50) ALDH1A1KDM4EPOLA1CDK2RXFP1
SCHEMBL6027523 0.82 ALDH1A1 (0.46) ALDH1A1KDM4EPOLA1CDK2RXFP1
SCHEMBL27568676 0.80 POLA1 (0.56) ALDH1A1KDM4EPOLA1CDK2RXFP1
SCHEMBL28231112 0.79 ALDH1A1 (0.50) ALDH1A1KDM4EPOLA1CDK2RXFP1
SCHEMBL27658630 0.79 ALDH1A1 (0.50) ALDH1A1KDM4EPOLA1CDK2RXFP1
SCHEMBL5138814 0.79 ALDH1A1 (0.53) ALDH1A1KDM4EPOLA1CDK2RXFP1
SCHEMBL3691693 0.79 POLA1 (0.51) ALDH1A1KDM4EPOLA1CDK2RXFP1
SCHEMBL27747326 0.79 ALDH1A1 (0.46) ALDH1A1KDM4EPOLA1CDK2RXFP1
SCHEMBL28252480 0.79 ALDH1A1 (0.46) ALDH1A1KDM4EPOLA1CDK2RXFP1
SCHEMBL3054589 0.78 ALDH1A1 (0.40) ALDH1A1KDM4EPOLA1CDK2RXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5849905-A Biologically active phosphotriester-type nucleosides and methods for preparing same CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 1998-12-15 US claimed
US-5770725-A USES NOVEL GROUP, CHARACTERIZED BY THE PRESENCE OF-S-S-AND/OR S-C=Z (Z=O OR S) ENZYME LABILE BONDS WHICH LEADS, AFTER ENZYMATIC ACTIVATION, TO THE FORMATION OF UNSTABLE INTERMEDIATE WHICH RELEASES MONOPHOSPHATE OR MONOPHOSPHONATE CENTER NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 1998-06-23 US claimed
EP-0642528-B1 PHOSPHOTRIESTER-TYPE BIOLOGICALLY ACTIVE COMPOUNDS CENTRE NAT RECH SCIENT (FR) 1997-01-15 EP claimed
EP-0642528-A1 PHOSPHOTRIESTER-TYPE BIOLOGICALLY ACTIVE COMPOUNDS. CENTRE NAT RECH SCIENT (FR) 1995-03-15 EP claimed
WO-1993024510-A1 PHOSPHOTRIESTER-TYPE BIOLOGICALLY ACTIVE COMPOUNDS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 1993-12-09 WO claimed
EP-1747022-A2 INHIBITION OF HAIRLESS PROTEIN mRNA The Trustees of Columbia University in the City of New York (US) 2007-01-31 EP disclosed
EP-1495041-A4 RNA INTERFERENCE MEDIATED INHIBITION OF G72 AND D-AMINO ACID OXIDASE (DAAO) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) SIRNA THERAPEUTICS INC (US) 2006-02-01 EP disclosed
EP-1470256-A4 RNA INTERFERENCE MEDIATED INHIBITION OF GASTRIC INHIBITORY POLYPEPTIDE /GIP) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) SIRNA THERAPEUTICS INC (US) 2006-01-25 EP disclosed
EP-1463842-A4 RNA INTERFERENCE MEDIATED INHIBITION OF PROTEIN KINASE C ALPHA (PKC-ALPHA) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) SIRNA THERAPEUTICS INC (US) 2006-01-25 EP disclosed
WO-2005105157-A2 INHIBITION OF HAIRLESS PROTEIN mRNA THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OFNEW YORK (US) 2005-11-10 WO disclosed
EP-1472267-A4 RNA INTERFERENCE MEDIATED INHIBITION OF PROTEIN TYROSINE PHOSPHATASE TYPE IVA (PRL3) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) SIRNA THERAPEUTICS INC (US) 2005-11-09 EP disclosed
EP-1476457-A4 RNA INTERFERENCE MEDIATED INHIBITION OF PROTEIN TYPROSINE PHOSPHATASE-1B (PTP-1B) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SiNA) RIBOZYME PHARM INC (US) 2005-08-31 EP disclosed
US-20020037873-A1 Biologically active phosphotriester-type compounds CENTRE NATIONAL DE LA RECHERCH SIENTIFIQUE 2002-03-28 US disclosed
US-6020482-A Phosphotriester type biologically active compounds CENTER NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 2000-02-01 US disclosed
US-5849905-A Biologically active phosphotriester-type nucleosides and methods for preparing same CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 1998-12-15 US disclosed
US-5770725-A USES NOVEL GROUP, CHARACTERIZED BY THE PRESENCE OF-S-S-AND/OR S-C=Z (Z=O OR S) ENZYME LABILE BONDS WHICH LEADS, AFTER ENZYMATIC ACTIVATION, TO THE FORMATION OF UNSTABLE INTERMEDIATE WHICH RELEASES MONOPHOSPHATE OR MONOPHOSPHONATE CENTER NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 1998-06-23 US disclosed
WO-1998011121-A1 BIOLOGICALLY ACTIVE PHOSPHOTRIESTER-TYPE COMPOUNDS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 1998-03-19 WO disclosed
EP-0642528-B1 PHOSPHOTRIESTER-TYPE BIOLOGICALLY ACTIVE COMPOUNDS CENTRE NAT RECH SCIENT (FR) 1997-01-15 EP disclosed
EP-0642528-A1 PHOSPHOTRIESTER-TYPE BIOLOGICALLY ACTIVE COMPOUNDS. CENTRE NAT RECH SCIENT (FR) 1995-03-15 EP disclosed
WO-1993024510-A1 PHOSPHOTRIESTER-TYPE BIOLOGICALLY ACTIVE COMPOUNDS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 1993-12-09 WO disclosed