SCHEMBL5482572

SCHEMBL5482572

OC[C@H]1O[C@@H](c2ccc(Br)nc2)[C@H](O)[C@@H]1O

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 17/20 0.48
PYGL P06737 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6934058 1.00 SLC5A2 (0.48) SLC5A2PYGL
SCHEMBL5482570 1.00 SLC5A2 (0.48) SLC5A2PYGL
SCHEMBL5483976 0.83 SLC5A2 (0.47) SLC5A2PYGL
SCHEMBL5486410 0.83 SLC5A2 (0.47) SLC5A2PYGL
SCHEMBL6788982 0.83 SLC5A2 (0.53) SLC5A2
SCHEMBL6789584 0.83 SLC5A2 (0.47) SLC5A2PYGL
SCHEMBL6786028 0.83 SLC5A2 (0.53) SLC5A2
SCHEMBL6789580 0.83 SLC5A2 (0.47) SLC5A2PYGL
Bromide SCHEMBL8817735 0.82 SLC5A2 (0.46) SLC5A2PYGL
SCHEMBL6789160 0.80 SLC5A2 (0.46) SLC5A2PYGL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-3903392-B2 2007-04-11 JP claimed
US-6248878-B1 INCLUDING BASES 2-FLUOROPYRIDINE-3-YL, PYRIDINE-2-ONE-3-YL, PYRIDIN-2-(4-NITROPHENYLETHYL)-ONE-3-YL, 2-BROMOPYRIDINE-5-YL , PYRIDIN-2-ONE-5-YL, 2-AMINOPYRIDINE-5-YL, PYRIDIN-2-(4-NITROPHENYLETHYL)-ONE-5-YL; ANTISENSE/ANTICANCER AGENTS RIBOZYME PHARMACEUTICALS, INC. 2001-06-19 US claimed
JP-2001507688-A 2001-06-12 JP claimed
EP-0948511-A2 CHEMICAL SYNTHESIS OF NUCLEOSIDES ANALOGS AND THEIR INCORPORATION INTO POLYNUCLEOTIDES RIBOZYME PHARMACEUTICALS, INC. (US) 1999-10-13 EP claimed
WO-1998028317-A2 SYNTHESIS OF NUCLEOSIDES AND POLYNUCLEOTIDES RIBOZYME PHARMACEUTICALS, INC. (US) 1998-07-02 WO claimed
EP-0948511-B1 CHEMICAL SYNTHESIS OF NUCLEOSIDES ANALOGS AND THEIR INCORPORATION INTO POLYNUCLEOTIDES SIRNA THERAPEUTICS INC (US) 2006-10-18 EP disclosed
US-20040266723-A1 Antiviral agents for treatment of Flaviviridae infections PHARMASSET, INC. 2004-12-30 US disclosed
CN-1527836-A Antiviral agents for treatment of flaviviridae infections 2004-09-08 CN disclosed
US-6248878-B1 INCLUDING BASES 2-FLUOROPYRIDINE-3-YL, PYRIDINE-2-ONE-3-YL, PYRIDIN-2-(4-NITROPHENYLETHYL)-ONE-3-YL, 2-BROMOPYRIDINE-5-YL , PYRIDIN-2-ONE-5-YL, 2-AMINOPYRIDINE-5-YL, PYRIDIN-2-(4-NITROPHENYLETHYL)-ONE-5-YL; ANTISENSE/ANTICANCER AGENTS RIBOZYME PHARMACEUTICALS, INC. 2001-06-19 US disclosed
US-6248878-B1 INCLUDING BASES 2-FLUOROPYRIDINE-3-YL, PYRIDINE-2-ONE-3-YL, PYRIDIN-2-(4-NITROPHENYLETHYL)-ONE-3-YL, 2-BROMOPYRIDINE-5-YL , PYRIDIN-2-ONE-5-YL, 2-AMINOPYRIDINE-5-YL, PYRIDIN-2-(4-NITROPHENYLETHYL)-ONE-5-YL; ANTISENSE/ANTICANCER AGENTS RIBOZYME PHARMACEUTICALS, INC. 2001-06-19 US disclosed
EP-0948511-A2 CHEMICAL SYNTHESIS OF NUCLEOSIDES ANALOGS AND THEIR INCORPORATION INTO POLYNUCLEOTIDES RIBOZYME PHARMACEUTICALS, INC. (US) 1999-10-13 EP disclosed
WO-1998028317-A2 SYNTHESIS OF NUCLEOSIDES AND POLYNUCLEOTIDES RIBOZYME PHARMACEUTICALS, INC. (US) 1998-07-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040266723-A1 Antiviral agents for treatment of Flaviviridae infections HAVCR2, MAVS, EIF2AK2 SLC5A2 309/4885PYGL 81/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.