Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CES2 | O00748 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 6/20 | 0.38 |
| ▸ | CA2 | P00918 | 6/20 | 0.38 |
| ▸ | CA9 | Q16790 | 6/20 | 0.38 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.38 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA3 | P07451 | 2/20 | 0.38 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8362606 | 1.00 | MEN1 (0.54) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL6759184 | 1.00 | MEN1 (0.54) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL5544295 | 1.00 | MEN1 (0.54) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL5428085 | 0.98 | MEN1 (0.50) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL5539506 | 0.98 | MEN1 (0.50) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL7209213 | 0.91 | MEN1 (0.48) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL5540017 | 0.91 | TSHR (0.50) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL1190989 | 0.91 | TSHR (0.50) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL7249899 | 0.89 | MEN1 (0.45) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL7252397 | 0.89 | MEN1 (0.45) | MEN1THRBHTTKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176234-B2 | Anticancer agents; side effect reduction | CYTOVIA, INC. (US) | 2007-02-13 | — | — | US | claimed |
| EP-1562598-A2 | DERIVATIVES OF GAMBOGIC ACID AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS | Cytovia, Inc. (US) | 2005-08-17 | — | — | EP | claimed |
| US-20040082066-A1 | Derivatives of gambogic acid and analogs as activators of caspases and inducers of apoptosis | CYTOVIA, INC. | 2004-04-29 | — | — | US | claimed |
| WO-2004002428-A2 | DERIVATIVES OF GAMBOGIC ACID AND INDUCE APOPTOSIS | CYTOVIA, INC. (US) | 2004-01-08 | — | — | WO | claimed |
| US-7176234-B2 | Anticancer agents; side effect reduction | CYTOVIA, INC. (US) | 2007-02-13 | — | — | US | disclosed |
| US-20040082066-A1 | Derivatives of gambogic acid and analogs as activators of caspases and inducers of apoptosis | CYTOVIA, INC. | 2004-04-29 | — | — | US | disclosed |