Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 10/20 | 0.56 |
| ▸ | CDK2 | P24941 | 10/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 10/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 10/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5495558 | 0.90 | CCNA2 (0.50) | CCNA2CDK2CDK5CDK5R1NPC1 | |
| SCHEMBL5485671 | 0.90 | CCNA2 (0.61) | CCNA2CDK2CDK5CDK5R1NPC1 | |
| SCHEMBL5482718 | 0.87 | CDK5 (0.51) | CCNA2CDK2CDK5CDK5R1NPC1 | |
| SCHEMBL5491314 | 0.86 | NPC1 (0.51) | CCNA2CDK2CDK5CDK5R1NPC1 | |
| SCHEMBL5484956 | 0.86 | GSK3A (0.57) | CCNA2CDK2CDK5CDK5R1NPC1 | |
| SCHEMBL5478195 | 0.85 | CDK4 (0.50) | CCNA2CDK2CDK5CDK5R1NPC1 | |
| SCHEMBL5482785 | 0.85 | CDK4 (0.56) | CCNA2CDK2CDK5CDK5R1NPC1 | |
| SCHEMBL4340868 | 0.83 | CCNA2 (0.58) | CCNA2CDK2CDK5CDK5R1NPC1 | |
| SCHEMBL5488900 | 0.83 | CDK5 (0.57) | CCNA2CDK2CDK5CDK5R1NPC1 | |
| SCHEMBL5483567 | 0.82 | CDK5 (0.48) | CCNA2CDK2CDK5CDK5R1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740576-A1 | NOVEL PIPERIDINE SUBSTITUTED DIAMINOTHIAZOLES | F. Hoffman-la Roche AG (CH) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005103034-A1 | NOVEL PIPERIDINE SUBSTITUTED DIAMINOTHIAZOLES | F. HOFFMAN-LA ROCHE AG (CH) | 2005-11-03 | — | — | WO | disclosed |