Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 3/20 | 0.61 |
| ▸ | CDK2 | P24941 | 3/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 10/20 | 0.61 |
| ▸ | CDK5R1 | Q15078 | 10/20 | 0.61 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | CDK4 | P11802 | 1/20 | 0.54 |
| ▸ | CCND1 | P24385 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | GSK3A | P49840 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | TUBB8B | A6NNZ2 | 1/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5483515 | 0.90 | CCNA2 (0.56) | CCNA2CDK2CDK5CDK5R1ZAP70 | |
| SCHEMBL5495558 | 0.89 | CCNA2 (0.50) | CCNA2CDK2CDK5CDK5R1ZAP70 | |
| SCHEMBL5484956 | 0.85 | GSK3A (0.57) | CCNA2CDK2CDK5CDK5R1MAPT | |
| SCHEMBL5482718 | 0.85 | CDK5 (0.51) | CCNA2CDK2CDK5CDK5R1MAPT | |
| SCHEMBL5481581 | 0.85 | TUBB8B (0.53) | CCNA2CDK2CDK5CDK5R1ZAP70 | |
| SCHEMBL5491314 | 0.84 | NPC1 (0.51) | CCNA2CDK2CDK5CDK5R1MAPT | |
| SCHEMBL5482785 | 0.83 | CDK4 (0.56) | CCNA2CDK2CDK5CDK5R1MAPT | |
| SCHEMBL5478195 | 0.83 | CDK4 (0.50) | CCNA2CDK2CDK5CDK5R1MAPT | |
| SCHEMBL5486124 | 0.81 | CCNA2 (0.47) | CCNA2CDK2CDK5CDK5R1ZAP70 | |
| SCHEMBL4478062 | 0.81 | CCNA2 (0.87) | CCNA2CDK2CDK5CDK5R1ZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740576-A1 | NOVEL PIPERIDINE SUBSTITUTED DIAMINOTHIAZOLES | F. Hoffman-la Roche AG (CH) | 2007-01-10 | — | — | EP | claimed |
| WO-2005103034-A1 | NOVEL PIPERIDINE SUBSTITUTED DIAMINOTHIAZOLES | F. HOFFMAN-LA ROCHE AG (CH) | 2005-11-03 | — | — | WO | claimed |