Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 6/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | SSTR5 | P35346 | 3/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | TACR1 | P25103 | 4/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5484199 | 0.92 | REN (0.39) | SLC6A2SLC6A4SLC6A3KCNH2SSTR5 | |
| SCHEMBL4863638 | 0.92 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3KCNH2SSTR5 | |
| SCHEMBL5488874 | 0.92 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3KCNH2SSTR5 | |
| SCHEMBL5486745 | 0.91 | SSTR5 (0.35) | SLC6A2SLC6A4SLC6A3KCNH2SSTR5 | |
| SCHEMBL1378950 | 0.91 | SSTR5 (0.35) | SLC6A2SLC6A4SLC6A3KCNH2SSTR5 | |
| SCHEMBL5482006 | 0.90 | SSTR5 (0.32) | SLC6A2SLC6A4SLC6A3KCNH2SSTR5 | |
| SCHEMBL5487199 | 0.87 | SSTR5 (0.32) | KCNH2SSTR5 | |
| SCHEMBL5488923 | 0.87 | SSTR5 (0.30) | KCNH2SSTR5 | |
| SCHEMBL5486955 | 0.85 | — | — | |
| SCHEMBL5486117 | 0.85 | REN (0.41) | SLC6A2SLC6A4SLC6A3SSTR5REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858901-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006094682-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-09-14 | — | — | WO | disclosed |