SCHEMBL5483900

SCHEMBL5483900

Clc1[c]c(Cl)c(Cl)nc1Cl

nearest known ligand 0.31

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.31
ALOX15 P16050 1/20 0.31
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8168461 0.73
SCHEMBL1392210 0.69
SCHEMBL5849008 0.69 ALDH1A1 (0.46) ALDH1A1ALOX15TSHR
SCHEMBL5462547 0.65
SCHEMBL1361208 0.65
SCHEMBL5522591 0.60
SCHEMBL68155 0.58 MEN1 (0.31) ALDH1A1TSHR
SCHEMBL468366 0.58 ALDH1A1 (0.36) ALDH1A1ALOX15TSHR
Potassium SCHEMBL8421932 0.56 ALDH1A1 (0.33) ALDH1A1ALOX15TSHR
SCHEMBL10414347 0.54 ALDH1A1 (0.43) ALDH1A1ALOX15TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060257613-A1 Metal complexes as light-absorbing compounds in the information layer of optical data carriers LANXESS DEUTSCHLAND GMBH (DE) 2006-11-16 US claimed
CN-1751101-A Metal complexes as light-absorbing compounds in the information layer of optical data carriers LANXESS DEUTSCHLAND GMBH (DE) 2006-03-22 CN claimed
EP-1597322-A2 METAL COMPLEXES AS LIGHT-ABSORBING COMPOUNDS IN THE INFORMATION LAYER OF OPTICAL DATA CARRIERS LANXESS Deutschland GmbH (DE) 2005-11-23 EP claimed
WO-2004087667-A1 ESTER DERIVATIVES OF (PYRIDINYLOXY-PHENYL)-METHANOL AND PROCESS OF PREPARATION THEREOF COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2004-10-14 WO claimed
WO-2004072087-A2 METAL COMPLEXES AS LIGHT-ABSORBING COMPOUNDS IN THE INFORMATION LAYER OF OPTICAL DATA CARRIERS LANXESS DEUTSCHLAND GMBH (DE) 2004-08-26 WO claimed
US-4167567-A Antihypertensive 4-aminoquinolines THE UPJOHN COMPANY (US) 1979-09-11 US claimed
CN-116963773-A Compositions and methods for treating tumors 浙江养生堂天然药物研究所有限公司 2023-10-27 CN disclosed
US-20070093531-A1 Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them ELBION AG 2007-04-26 US disclosed
US-7166637-B2 Hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them ELBION AG (DE) 2007-01-23 US disclosed
US-20060257613-A1 Metal complexes as light-absorbing compounds in the information layer of optical data carriers LANXESS DEUTSCHLAND GMBH (DE) 2006-11-16 US disclosed
CN-1751101-A Metal complexes as light-absorbing compounds in the information layer of optical data carriers LANXESS DEUTSCHLAND GMBH (DE) 2006-03-22 CN disclosed
EP-1597322-A2 METAL COMPLEXES AS LIGHT-ABSORBING COMPOUNDS IN THE INFORMATION LAYER OF OPTICAL DATA CARRIERS LANXESS Deutschland GmbH (DE) 2005-11-23 EP disclosed
WO-2004087667-A1 ESTER DERIVATIVES OF (PYRIDINYLOXY-PHENYL)-METHANOL AND PROCESS OF PREPARATION THEREOF COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2004-10-14 WO disclosed
US-6281204-B1 ANTIESTROGENS Roussel, Hoechst Marion (FR) 2001-08-28 US disclosed
EP-0623140-B1 NOVEL 19-NOR STEROIDS HAVING A THIOCARBON-CONTAINING CHAIN IN THE 11BETA POSITION, A METHOD FOR PREPARING SAME AND INTERMEDIATES THEREFOR, MEDICINAL USES THEREOF AND COMPOSITIONS CONTAINING SAID STEROIDS HOECHST MARION ROUSSEL INC (FR) 1998-04-22 EP disclosed
CN-1036718-C Steroid, preparing processing, intermediate and application ROUSSEL UCLAF (FR) 1997-12-17 CN disclosed
EP-0623140-A1 NOVEL 19-NOR STEROIDS HAVING A THIOCARBON-CONTAINING CHAIN IN THE 11BETA POSITION, A METHOD FOR PREPARING SAME AND INTERMEDIATES THEREFOR, MEDICINAL USES THEREOF AND COMPOSITIONS CONTAINING SAID STEROIDS ROUSSEL UCLAF (FR) 1994-11-09 EP disclosed
CN-1075722-A New steroide and method for making thereof, intermediate and application ROUSSEL UCLAF (FR) 1993-09-01 CN disclosed
WO-1993013123-A1 NOVEL 19-NOR STEROIDS HAVING A THIOCARBON-CONTAINING CHAIN IN THE 11BETA POSITION, A METHOD FOR PREPARING SAME AND INTERMEDIATES THEREFOR, MEDICINAL USES THEREOF AND COMPOSITIONS CONTAINING SAID STEROIDS ROUSSEL-UCLAF (FR) 1993-07-08 WO disclosed
US-4140778-A N-pyridyl-N-phenylamines as rodenticides ELI LILLY AND COMPANY (US) 1979-02-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070093531-A1 Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them PDE4B, PDE4A, PDE4D ALDH1A1 1815/4885ALOX15 254/4885TSHR 3783/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.