SCHEMBL5483908

SCHEMBL5483908

CC(=O)Oc1cc(Br)c(Oc2cc(C=O)c(O)c(C(C)C)c2)c(Br)c1

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRA P10827 14/20 0.55
THRB P10828 14/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5291072 0.85 THRA (0.46) THRATHRB
SCHEMBL5964844 0.83 THRA (0.58) THRATHRB
SCHEMBL5291080 0.80 THRA (0.54) THRATHRB
SCHEMBL5038181 0.77 THRA (0.47) THRATHRB
SCHEMBL13057611 0.74 GAA (0.52) THRATHRB
SCHEMBL5037665 0.73 THRA (0.44) THRATHRB
SCHEMBL4879195 0.72 ERN1 (0.49)
SCHEMBL5045356 0.72 THRA (0.50) THRATHRB
SCHEMBL5544018 0.71 THRA (1.00) THRATHRB
SCHEMBL5964560 0.71 THRA (0.44) THRATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1537073-B1 BENZAMIDE OR PHENYLACETAMIDE DERIVATIVES USEFUL AS THYROID RECEPTOR LIGANDS KAROBIO AB (SE) 2007-09-12 EP disclosed