Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 9/20 | 0.56 |
| ▸ | HRH1 | P35367 | 4/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5485765 | 0.92 | SSTR5 (0.57) | SSTR5HRH1KCNH2SSTR1CA12 | |
| SCHEMBL1380597 | 0.91 | SSTR5 (0.48) | SSTR5HRH1KCNH2SSTR1CA12 | |
| SCHEMBL5486591 | 0.90 | SSTR5 (0.43) | SSTR5HRH1KCNH2SLC6A2SLC6A4 | |
| SCHEMBL5482371 | 0.89 | SSTR5 (0.48) | SSTR5HRH1 | |
| SCHEMBL5485881 | 0.89 | SSTR5 (0.49) | SSTR5HRH1KCNH2SSTR1CA12 | |
| SCHEMBL5483662 | 0.89 | SSTR5 (0.47) | SSTR5HRH1KCNH2SSTR1CA12 | |
| SCHEMBL5483072 | 0.89 | SSTR5 (0.46) | SSTR5HRH1KCNH2SSTR1CA12 | |
| SCHEMBL5487222 | 0.88 | SSTR5 (0.57) | SSTR5HRH1KCNH2SLC6A2SLC6A4 | |
| SCHEMBL5492473 | 0.88 | SSTR5 (0.43) | SSTR5HRH1SSTR1CA12CA1 | |
| SCHEMBL5484816 | 0.86 | SSTR5 (0.48) | SSTR5HRH1KCNH2SSTR1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858901-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006094682-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-09-14 | — | — | WO | disclosed |