Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 15/20 | 0.57 |
| ▸ | HRH1 | P35367 | 5/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | REN | P00797 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1380597 | 0.93 | SSTR5 (0.48) | SSTR5HRH1KCNH2HTR2BSLC6A2 | |
| SCHEMBL5484816 | 0.92 | SSTR5 (0.48) | SSTR5HRH1KCNH2SLC6A2SLC6A4 | |
| SCHEMBL5483662 | 0.92 | SSTR5 (0.47) | SSTR5HRH1KCNH2SLC6A2SLC6A4 | |
| SCHEMBL5485881 | 0.92 | SSTR5 (0.49) | SSTR5HRH1KCNH2HTR2BSLC6A2 | |
| SCHEMBL5485765 | 0.91 | SSTR5 (0.57) | SSTR5HRH1KCNH2SLC6A2SLC6A4 | |
| SCHEMBL5484170 | 0.88 | SSTR5 (0.56) | SSTR5HRH1KCNH2SLC6A2SLC6A4 | |
| SCHEMBL1379151 | 0.87 | SSTR5 (0.56) | SSTR5HRH1KCNH2HTR2BSLC6A2 | |
| SCHEMBL5483072 | 0.87 | SSTR5 (0.46) | SSTR5HRH1KCNH2SLC6A2SLC6A4 | |
| SCHEMBL5486591 | 0.86 | SSTR5 (0.43) | SSTR5HRH1KCNH2SLC6A2SLC6A4 | |
| SCHEMBL4593454 | 0.85 | SSTR5 (0.42) | SSTR5HRH1KCNH2RENHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858901-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006094682-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-09-14 | — | — | WO | disclosed |