Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.84 |
| ▸ | JAK2 | O60674 | 4/20 | 0.62 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.57 |
| ▸ | INSR | P06213 | 3/20 | 0.57 |
| ▸ | MAP4K3 | Q8IVH8 | 2/20 | 0.57 |
| ▸ | PLK4 | O00444 | 2/20 | 0.57 |
| ▸ | AURKA | O14965 | 2/20 | 0.57 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.57 |
| ▸ | ABL1 | P00519 | 2/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.57 |
| ▸ | LCK | P06239 | 2/20 | 0.57 |
| ▸ | FES | P07332 | 2/20 | 0.57 |
| ▸ | CSF1R | P07333 | 2/20 | 0.57 |
| ▸ | LYN | P07948 | 2/20 | 0.57 |
| ▸ | RET | P07949 | 2/20 | 0.57 |
| ▸ | IGF1R | P08069 | 2/20 | 0.57 |
| ▸ | ROS1 | P08922 | 2/20 | 0.57 |
| ▸ | SRC | P12931 | 2/20 | 0.57 |
| ▸ | FER | P16591 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30453276 | 0.92 | MET (1.00) | METJAK2ALKINSRMAP4K3 | |
| SCHEMBL30454334 | 0.92 | MET (1.00) | METJAK2ALKINSRMAP4K3 | |
| SCHEMBL488336 | 0.92 | MET (1.00) | METJAK2ALKINSRMAP4K3 | |
| SCHEMBL488041 | 0.92 | MET (1.00) | METJAK2ALKINSRMAP4K3 | |
| SCHEMBL5252099 | 0.91 | MET (0.80) | METJAK2ALKINSRMAP4K3 | |
| SCHEMBL30452860 | 0.91 | MET (0.80) | METJAK2ALKINSRMAP4K3 | |
| SCHEMBL3113354 | 0.91 | MET (0.80) | METJAK2ALKINSRMAP4K3 | |
| SCHEMBL488694 | 0.91 | MET (0.80) | METJAK2ALKINSRMAP4K3 | |
| SCHEMBL30453504 | 0.89 | MET (0.75) | METJAK2ALKINSRMAP4K3 | |
| SCHEMBL488666 | 0.89 | MET (0.75) | METJAK2ALKINSRMAP4K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230098-B2 | 2-amino- pyridines and pyrazines additionally substituted witn one or more carbocyclic or heterocyclic groups, e.g., 4-[6-amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-phenol, for treating many kinds of cancer | SUGEN, INC. (US) | 2007-06-12 | — | — | US | disclosed |
| US-20050009840-A1 | 2-amino- pyridines and pyrazines additionally substituted witn one or more carbocyclic or heterocyclic groups, e.g., 4-[6-amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-phenol, for treating many kinds of cancer | SUGEN, INC. | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009840-A1 | 2-amino- pyridines and pyrazines additionally substituted witn one or more carbocyclic or heterocyclic groups, e.g., 4-[6-amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-phenol, for treating many kinds of cancer | MET, ERBB2, CDK4 | MET 1/4885JAK2 8/4885ALK 54/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.