Sugi Predict

Sugi Predict / Compounds / SCHEMBL5484493

SCHEMBL5484493

SCHEMBL5484493

COc1cc2c(cc1OC)C1CC(O)CCC1N=C2c1ccc(C(=O)N(C)C)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDE4D Q08499 6/20 0.53
▸ PDE4B Q07343 4/20 0.53
▸ PDE4A P27815 3/20 0.53
▸ PDE4C Q08493 2/20 0.53
▸ ERN1 O75460 1/20 0.37
▸ CYP1A2 P05177 4/20 0.37
▸ CYP3A4 P08684 4/20 0.37
▸ CYP2D6 P10635 4/20 0.37
▸ HSD17B10 Q99714 2/20 0.37
▸ CYP2C19 P33261 2/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ TSHR P16473 2/20 0.35
▸ CLK4 Q9HAZ1 2/20 0.35
▸ FYN P06241 1/20 0.35
▸ ALOX15 P16050 1/20 0.35
▸ USP2 O75604 2/20 0.34
▸ ALDH1A1 P00352 2/20 0.34
▸ SLC6A2 P23975 1/20 0.34
▸ SLC6A4 P31645 1/20 0.34
▸ LRRK2 Q5S007 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5480706 0.94 PDE4D (0.50) PDE4DPDE4BPDE4APDE4CERN1
SCHEMBL5480760 0.89 PDE4D (0.51) PDE4DPDE4BPDE4APDE4CCYP1A2
SCHEMBL5484482 0.85 PDE4D (0.74) PDE4DPDE4BPDE4APDE4CMAPK1
SCHEMBL5476545 0.85 PDE4D (0.51) PDE4DPDE4BPDE4APDE4CCYP1A2
SCHEMBL5477321 0.85 PDE4D (0.46) PDE4DPDE4BPDE4APDE4CFYN
SCHEMBL6385166 0.84 PDE4D (0.52) PDE4DPDE4BPDE4APDE4CALDH1A1
SCHEMBL6390493 0.83 PDE4D (0.43) PDE4DPDE4BPDE4APDE4CALDH1A1
SCHEMBL6385822 0.82 PDE4D (0.47) PDE4DPDE4BPDE4APDE4CMAPK1
SCHEMBL6386266 0.82 PDE4D (0.57) PDE4DPDE4BPDE4APDE4CCYP1A2
SCHEMBL2265798 0.82 PDE4D (0.41) PDE4DPDE4BPDE4APDE4CTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070185149-A1 Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors ALTANA PHARMA AG (DE) 2007-08-09 — — US claimed
EP-1725534-A1 NOVEL AMIDO-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS Altana Pharma AG (DE) 2006-11-29 — — EP claimed
WO-2005087745-A1 NOVEL AMIDO-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS ALTANA PHARMA AG (DE) 2005-09-22 — — WO claimed
US-20070185149-A1 Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors ALTANA PHARMA AG (DE) 2007-08-09 — — US disclosed
EP-1725534-A1 NOVEL AMIDO-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS Altana Pharma AG (DE) 2006-11-29 — — EP disclosed
WO-2005087745-A1 NOVEL AMIDO-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS ALTANA PHARMA AG (DE) 2005-09-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070185149-A1 Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors PDE4A, PDE4B, PDE4C PDE4D 4/4885PDE4B 2/4885PDE4A 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.